FlyBase Allele Report: Dmel\w[1]

General Information

Symbol

Dmel\w¹

Species

D. melanogaster

Name

FlyBase ID

FBal0018074

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

Doc{}w¹

Carried in Construct

Also Known As

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

loss of function allele

amorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Judd, 1995)

hypomorphic allele - genetic evidence

(Lloyd et al., 2002)

loss of function allele

(Sabl and Birchler, 1993)

Mutagen

spontaneous

(Driver et al., 1989, Zachar and Bingham, 1982)

Progenitor genotype

Associated Insertion(s)

Doc{}w¹

Cytology

Description

Insertion of a Doc element.

(Judd, 1995)

Insertion of a 5.7kb Doc element.

(Sabl and Birchler, 1993)

Insertion of Doc element at +3700bp.

(Dalby and O'Hare, 1991)

Doc element inserted into w promoter region.

(O'Hare et al., 1991)

Insertion of Doc element into the proximal region of w.

(O'Hare, 1991)

Insertion of 4.9kb Doc element, close to the site of transcription initiation. 13bp of w sequence from +3700 to +3688 is duplicated, and is present at both ends of the Doc insertion (nucleotide positions as in FBrf0041384). The Doc element is inserted in the same orientation as the direction of w transcription.

(Driver et al., 1989)

5kb Doc insert at +3.71; Origin = insertion of w^a copia; '-' values to left (telomere) end; '+' values to right (centromere) end.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:2,796,485..2,796,497 [-]

(Judd, 1995, Sabl and Birchler, 1993, Dalby and O'Hare, 1991, O'Hare, 1991, O'Hare et al., 1991, Driver et al., 1989)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior | chemical conditional

(Lee et al., 2008)

abnormal eye color

(Lloyd et al., 2002, Smolik-Utlaut and Gelbart, 1987, Gehring et al., 1984, Plough and Ives, 1934)

abnormal eye color | recessive

(Pastink et al., 1987, Kaufman, 1969)

decreased rate of copulation

(Xiao et al., 2017)

visible | recessive

(Gehring et al., 1984)

Phenotype Manifest In

Malpighian tubule

(Gehring et al., 1984)

ocellus pigment granule

(Gehring et al., 1984)

ommatidium

(Ferreiro et al., 2017)

pigment cell

(Lloyd et al., 2002, Pastink et al., 1987, Smolik-Utlaut and Gelbart, 1987, Gehring et al., 1984, Zachar and Bingham, 1982, Kaufman, 1969, Plough and Ives, 1934)

retina

(Ferreiro et al., 2017)

testis pigment cell

(Gehring et al., 1984)

Detailed Description

Statement

Reference

w¹ adults exhibit spaces devoid of ommatidia in the retina when compared to controls.

(Ferreiro et al., 2017)

Mutant males display negligible intermale courtship upon recurring ethanol administration with 70% ethanol, in contrast to wild-type males which show intermale courtship after repeated ethanol exposure.

(Lee et al., 2008)

Homozygotes have white eyes with only <1% red pigment (compared to 100% pigment in wild type).

(Lloyd et al., 2002)

Bleach white eyes.

(O'Hare et al., 1991)

Eye colour: w^sp1/w¹ flies have brown eyes at eclosion, which become somewhat darker with age.

(Pastink et al., 1987)

White eye colour, suppresses z¹.

(Smolik-Utlaut and Gelbart, 1987)

Eye colour: white. Ocellus colour: colourless. Testis colour: colourless. Malpighian tubule colour: colourless.

(Gehring et al., 1984)

Eye colour: bleach white.

(Zachar and Bingham, 1982)

Eye colour: The w^cf2 eye colour is not diluted when w^cf2 is in transheterozygous combination with w¹.

(Kaufman, 1969)

Eye colour: w^dil/w¹ flies have darker eyes than g¹ and lighter eyes than pn¹.

(Plough and Ives, 1934)

Eye colour: white. Ocellus colour: colourless. Testis colour: colourless. Malpighian tubule colour: colourless. Eye colour: brown at eclosion, darker after 4-5 days, as w¹/w^sp1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

w¹/w^e(g) is an enhancer of abnormal eye color phenotype of g^53d

(Lloyd et al., 2002)

w¹/w^e(g) is an enhancer of abnormal eye color phenotype of g²

(Lloyd et al., 2002)

w¹/w^e(g) is an enhancer of abnormal eye color phenotype of g^50e

(Lloyd et al., 2002)

Other

Statement

Reference

su(f)⁴/su(f)¹, w¹ has abnormal eye color phenotype

(Schalet, 1972)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

w¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

w¹/w^e(g) is an enhancer of pigment cell phenotype of g^53d

(Lloyd et al., 2002)

w¹/w^e(g) is an enhancer of pigment cell phenotype of g²

(Lloyd et al., 2002)

w¹/w^e(g) is an enhancer of pigment cell phenotype of g^50e

(Lloyd et al., 2002)

Suppressor of

Statement

Reference

w¹ is a suppressor of phenotype of z¹

(Judd, 1995)

Other

Statement

Reference

su(f)⁴/su(f)¹, w¹ has pigment cell phenotype

(Schalet, 1972)

Additional Comments

Genetic Interactions

Statement

Reference

Flies with a w¹/w^e(g) mutant genotype enhance the eye colour defective phenotype of g², g^50e and g^53d homozygous mutants leading to a greater reduction of red pigment in the eye.

(Lloyd et al., 2002)

A suppressor of the repression on w by z¹.

(Judd, 1995)

w¹ su(f)⁴/w^a su(f)¹ females have a w¹ phenotype at 24-25^oC. w^a su(f)⁴/Y males have an eye colour intermediate between that of w¹ and w^a at 17-18^oC.

(Schalet, 1972)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

w^sp1

Partially complements

w^sp1

(Green, 1959)

Rescued by

w¹ is rescued by w^+t12

(Gehring et al., 1984)

Partially rescued by

w¹ is partially rescued by w^+tAR

(Lloyd et al., 2002)

w¹ is partially rescued by w^+mC

(Lloyd et al., 2002)

w¹ is partially rescued by w^HSBJ

(Lloyd et al., 2002)

Comments

Images (2)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (781)

Bloomington

145

w¹

2390

w¹

1495

y¹ w¹

5298

w¹ dsh¹

24619

w¹; P{UAS-fh.A}1

Kyoto

101196

w¹

105757

w¹

107303

w¹

106349

y¹ w¹

103167

w¹ ; P{GAL4}10.2

103168

w¹ ; P{GAL4}12.1

103170

w¹ ; P{GAL4}26.1

More stocks available...

Notes on Origin

Discoverer

Morgan, March 1910.

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

X17551

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

(Pastink et al., 1987, Schalet, 1972, Plough and Ives, 1934)

(Soriano et al., 1997)

w¹

(Muron et al., 2022, Bosch et al., 2021, Groen et al., 2018, Ferreiro et al., 2017, Xiao et al., 2017, Singh et al., 2009, Lee et al., 2008)

white¹

(Bragina et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (67)

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