FlyBase Allele Report: Dmel\y[2S]

General Information

Symbol

Dmel\y^2S

Species

D. melanogaster

Name

2 from Swedish

FlyBase ID

FBal0018615

Feature type

allele

Associated gene

Dmel\y

Associated Insertion(s)

?{}y^2S

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Drapeau et al., 2006)

Mutagen

spontaneous

(Morris et al., 1999, Chia et al., 1986)

Progenitor genotype

Associated Insertion(s)

?{}y^2S

Cytology

Description

Structural alteration in the promoter.

(Morris et al., 1999)

Insertion of DNA into the regulatory region of y.

(Georgiev and Gerasimova, 1989)

4.5kb insertion 5' to the start of transcription, within the 489bp HindIII/BalI fragment.

(Chia et al., 1986)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

S57430

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color

(Drapeau et al., 2006, Chia et al., 1986)

abnormal mating | male

(Drapeau et al., 2006)

Phenotype Manifest In

adult

(Drapeau et al., 2006)

adult cuticle

(Chia et al., 1986)

chaeta

(Drapeau et al., 2006)

embryonic/larval mouth

(Drapeau et al., 2006)

sex comb

(Drapeau et al., 2006)

wing

(Drapeau et al., 2006)

Detailed Description

Statement

Reference

y^2S males have significantly reduced mating success compared to control males. The Dp(1;f)1187 minichromosome rescues the mating success of these mutants. y^2S adults show a reduction in pigmentation in the wing and a partial reduction in the body, bristles and sex combs. Larval mouth pigmentation is also reduced.

(Drapeau et al., 2006)

Similar to y²⁵.

(Morris et al., 1999)

Body colour: type 2 allele - some areas of cuticle are wild type, others have mutant pigmentation.

(Chia et al., 1986)

Body colour: body yellow, but darker than that of y²; bristles lighter. Larval mouth part colour: golden-brown; mouth-hooks light.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

y^2S has phenotype, non-enhanceable by mod(mdg4)^ul

(Georgiev and Gerasimova, 1989)

Suppressed by

Statement

Reference

y^2S has phenotype, suppressible | partially by su(Hw)²

(Lindsley and Grell, 1968)

NOT suppressed by

Statement

Reference

y^2S has phenotype, non-suppressible by mod(mdg4)^ul

(Georgiev and Gerasimova, 1989)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

y^82f29

(Morris et al., 1999)

y²³⁷⁴

(Morris et al., 1999)

y^62a

(Morris et al., 1999)

y²

(Morris et al., 1999)

Fails to complement

y^59b

(Morris et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

194

105781

Notes on Origin

Discoverer

Bridges.

Comments

Allelic series of reduced male mating success phenotype: y^59b = y^D91 >= y^3d > y^a77 >= y^2S.

(Drapeau et al., 2006)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

S57430

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

y^2S

y^2s

(Krachinska et al., 1992, Chia et al., 1986, Alexandrov et al., 1985)

Name Synonyms

2 from Swedish

Secondary FlyBase IDs

References (14)

Report Sections

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