FlyBase Allele Report: Dmel\Asx[P1]

General Information

Symbol

Dmel\Asx^P1

Species

D. melanogaster

Name

FlyBase ID

FBal0029010

Feature type

allele

Associated gene

Dmel\Asx

Associated Insertion(s)

P{}Asx^P1

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Sinclair et al., 1992)

Mutagen

P-element activity

(Sinclair et al., 1992)

Progenitor genotype

Associated Insertion(s)

P{}Asx^P1

Cytology

Description

P-element insertion 182bp downstream of the 5' end of the cDNA, 256bp upstream of the translation start.

(Sinclair et al., 1998)

A P element insertion at cytological location 51A5--51A6.

(Sinclair et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Milne et al., 1999, Salinas et al., 1998, Sinclair et al., 1992)

visible | homeotic

(Milne et al., 1999, Sinclair et al., 1992)

Phenotype Manifest In

abdominal tergite 5

(Milne et al., 1999)

abdominal tergite 6

(Milne et al., 1999)

adult abdominal segment 3

(Milne et al., 1999)

adult abdominal segment 4

(Milne et al., 1999)

haltere

(Milne et al., 1999)

Detailed Description

Statement

Reference

Homozygotes show trx-G like phenotypes. In 10-20% of male flies abdominal tergites 5 or 6 are transformed towards a more anterior segment (judged by pigmentation) and the halteres are transformed towards wing (with penetrance of about 20%). Posterior transformation characteristic of Pc-G mutations are also seen. Third or fourth abdominal segment become more posterior.

(Milne et al., 1999)

Adult Asx^P1 homozygotes show anterior and posterior directed homeotic transformations in the same individuals. This suggests that changes in Asx^P1 chromatin structure make homeotic gene activation and repression more difficult.

(Sinclair et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Asx^P1, Df(2R)trix has partially lethal - majority die phenotype

(Sinclair et al., 1992)

Phenotype Manifest In

Enhanced by

Statement

Reference

Asx^P1 has haltere phenotype, enhanceable by trx^B11

(Milne et al., 1999)

Enhancer of

Statement

Reference

Asx^P1/Asx[+] is an enhancer of adult abdominal segment 4 | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

Asx^P1/Asx[+] is an enhancer of adult abdominal segment 5 phenotype of E(z)^Trm

(Bajusz et al., 2001)

Asx^P1 is an enhancer of abdominal segment phenotype of Pc⁴

(Milne et al., 1999)

Asx^P1 is an enhancer of sex comb phenotype of Pc⁴

(Milne et al., 1999)

Asx^P1 is an enhancer of phenotype of trx^Z11

(Milne et al., 1999)

Suppressor of

Statement

Reference

Asx^P1/Asx[+] is a suppressor of adult mesothoracic segment | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

Asx^P1/Asx[+] is a suppressor of adult metathoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

Other

Statement

Reference

Asx^P1, trx^B11 has adult metathoracic segment phenotype

(Milne et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

In combination with trx^B11, the haltere is much enlarged over that seen for Asx^P1 alone, T3 is partially transformed towards T2. These phenotypes have a penetrance of close to 100%. Asx^P1 enhances both the penetrance and expressivity of trx^Z11. Asx^P1 strongly enhances the extra sex combs phenotype and abdominal homeotic transformations associated with Pc⁴.

(Milne et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Asx^P1

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close