FlyBase Allele Report: Dmel\capu[HK3]

General Information

Symbol

Dmel\capu^HK3

Species

D. melanogaster

Name

FlyBase ID

FBal0030718

Feature type

allele

Associated gene

Dmel\capu

Associated Insertion(s)

Carried in Construct

Also Known As

capu^HK

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Schupbach and Wieschaus, 1991, Manseau and Schupbach, 1989)

Progenitor genotype

Cytology

Description

Amino acid replacement: I750T.

(Emmons et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:3,873,891..3,873,891 [-]

Nucleotide change:

T3873891C

Amino acid change:

Reported amino acid change:

I750T|FBrf0083891

Comment:

Site of nucleic acid difference inferred by FlyBase curator based on reported amino acid change; CDS from reference sequence longer by 1 amino acid than published CDS in GB:U34258 and thus the mutation coordinates differ by 1

(Emmons et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Schupbach and Wieschaus, 1991)

lethal | maternal effect | recessive

(Manseau and Schupbach, 1989)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous egg chambers do not contain binucleate cells.

(Jackson and Berg, 1999)

hts RNA localization unaltered in embryos derived from capu mutant mothers.

(Ding et al., 1993)

Variable expansion (dorsalization) of dorsal appendages, at expense of main body shell. Absence of polar granules, pole cells and abdominal segments in embryos.

(Schupbach and Wieschaus, 1991)

Homozygous mothers produce dorsalized egg shells and embryos. The first sign of dorsalization in embryos can be seen during gastrulation, when the ventral furrow is reduced or absent. Dorsalization in the egg chamber is evident in the shape of the follicle cells. While the number of follicle cells around the main body of the egg shell is reduced, dorsal appendages are expanded, often fused dorsally and/or extended ventrally. The embryos lack polar granules and pole cells, and show cellularization defects. Embryos show abdominal segmentation defects similar to those produced by mutations in the grandchildless-knirps or posterior class of maternal effect loci. A small fraction of the offspring survive to adulthood, and are agametic.

(Manseau and Schupbach, 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Ets97D^tne-1/Df(3R)ro80b, capu[+]/capu^HK3 has decreased fecundity | female phenotype

(Gajewski and Schulz, 1995)

Phenotype Manifest In

Enhancer of

Statement

Reference

capu[+]/capu^HK3 is an enhancer of phenotype of ct^db7

(Jackson and Berg, 1999)

capu[+]/capu^HK3 is an enhancer of phenotype of ct^L188

(Jackson and Berg, 1999)

capu[+]/capu^HK3 is an enhancer of phenotype of ct^C145

(Jackson and Berg, 1999)

capu[+]/capu^HK3 is an enhancer of egg phenotype of Ets97D^tne-1

(Gajewski and Schulz, 1995)

Other

Statement

Reference

capu^HK3, ct^C145 has egg chamber phenotype

(Jackson and Berg, 1999)

capu^HK3, ct^L188 has egg chamber phenotype

(Jackson and Berg, 1999)

capu^HK3, ct^db7 has egg chamber phenotype

(Jackson and Berg, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

capu^HK3 does not interact with ct^C145 in a doubly heterozygous background, although it does enhance the frequency of binucleate cell production in the egg chambers of ct^C145/ct^L188 animals. capu^HK3 does not interact with ct^db7 in a doubly heterozygous background, although it does enhance the frequency of binucleate cell production in the egg chambers of ct^db7/ct^L188 animals.

(Jackson and Berg, 1999)

One copy of capu^HK3 decreases the number of eggs laid by Ets97D^tne-1/Df(3R)ro80b females.

(Gajewski and Schulz, 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Does not interact with RpII140^wimp maternal effect.

(Parkhurst and Ish-Horowicz, 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

capu^HK3

capu^HK

(Serbus et al., 2005, Emmons et al., 1995, Ding et al., 1994, Ephrussi et al., 1991, St. Johnston et al., 1991)

Name Synonyms

Secondary FlyBase IDs

FBal0030719

References (12)

Report Sections

Open Close