FlyBase Allele Report: Dmel\hry[i22]

General Information

Symbol

Dmel\hryⁱ²²

Species

D. melanogaster

Name

FlyBase ID

FBal0031449

Feature type

allele

Associated gene

Dmel\hry

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Howard and Ingham, 1986)

loss of function allele

(Abu-Issa and Cavicchi, 1996)

Mutagen

X ray

(Hooper et al., 1989, Ingham et al., 1985)

ethyl methanesulfonate

(Wainwright and Ish-Horowicz, 1992)

Progenitor genotype

Caused by aberration

Df(3L)hry-i22

Cytology

Description

Deletion of sequences encoding the h protein.

(Wainwright and Ish-Horowicz, 1992)

Deletion of the en protein coding sequences.

(Hooper et al., 1989)

Deletion of the sequences encoded in the h transcript.

(Howard and Ingham, 1986)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Fasano et al., 1988)

lethal | recessive

(Abu-Issa and Cavicchi, 1996, Wainwright and Ish-Horowicz, 1992, Hooper et al., 1989, Howard and Ingham, 1986, Ingham et al., 1985)

pair rule phenotype

(Fasano et al., 1988, Howard and Ingham, 1986)

pair rule phenotype | recessive

(Howard and Ingham, 1986)

visible | dominant

(Abu-Issa and Cavicchi, 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

hⁱ²²/+ first instar larvae only rarely have segmentation defects.

(Bullock et al., 2004)

hⁱ²²/h⁶⁷⁴ embryos have salivary glands with either branched or expanded lumens.

(Myat and Andrew, 2002)

Heterozygotes frequently have terminal incisions in the wing.

(Abu-Issa and Cavicchi, 1996)

Interacts with RpII140^wimp maternal effect.

(Parkhurst and Ish-Horowicz, 1991)

Transheterozygotes with h^L43a are lethal, strong pair-rule phenotype.

(Fasano et al., 1988)

Homozygous phenotype is variable. In some cases half the normal number of denticle bands form, due to a deletion of pattern elements from approximately the middle of one segment to a homologous position in the next segment ("pair-rule segmentation phenotype"). In other cases the deletions span more than one segment, resulting in the fusion of the compound segments. Weaker phenotypes are also seen, involving the formation of denticles corresponding to A2, A6 or both. Heterozygotes show some cuticle pattern defects.

(Howard and Ingham, 1986)

Class IV allele: has a strong segmentation phenotype either when homozygous or in trans with h²⁵, and fails to complement the bristle phenotype of h¹. The denticle belts associated with the A3/4 and A5/6 composite segments are often fused in homozygous larvae.

(Ingham et al., 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

hryⁱ²², rgr^KG03110 has partially lethal phenotype