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General Information
Symbol
Dmel\sr155
Species
D. melanogaster
Name
FlyBase ID
FBal0032779
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    C18130706T

    Reported nucleotide change:

    C198834T

    Amino acid change:

    Q596term | sr-PA; Q316term | sr-PB; Q596term | sr-PD; Q316term | sr-PE

    Reported amino acid change:

    Q590term,Q316term

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Single nucleotide substitution resulting in a premature stop codon which corresponds to residue Q590 in the srA isoform and to residue Q316 in the srB isoform.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    sr155 mutants display tracheal migration phenotypes.

    ligament attachment cells are missing from the lch5 abdominal lateral pentascolopidial chordotonal organ s of stage 16 sr155/Df(3R)DG4. These organs also occasionally lack one or both cap attachment cells, which when present are deformed.

    In sr155/Df(3R)DG4 embryos, stalled migration of the dorsal branch, dorsal trunk and ganglionic branches is seen. In spite of stalled migration, thin cytoplasmic extensions in the correct direction are seen. Defective migration of the visceral branch is also seen. Muscle migration is also abnormal.

    At stage 16 myotubes extend elongated membrane processes that often bifurcate in different directions, often these processes cross the ventral midline. In fully differentiated embryos the myotubes fail to fuse to the epidermis and instead attach to other myotubes.

    Double heterozygotes with sr6, sr461, srR947, Df(3R)P14 and sr61j are lethal, double heterozygotes with sr254 and sr410 have muscular defects and double heterozygotes with sr1 and sr5 have muscular and cuticular defects.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressor of
    Statement
    Reference

    sr155/sr[+] is a suppressor of abnormal cell migration phenotype of ptcD130

    NOT Suppressor of
    Statement
    Reference

    sr155 is a non-suppressor of abnormal cell migration phenotype of ptcD130

    Other
    Statement
    Reference
    Phenotype Manifest In
    Suppressor of
    Statement
    Reference

    sr155/sr[+] is a suppressor of embryonic/larval tracheal system phenotype of ptcD130

    NOT Suppressor of
    Statement
    Reference
    Other
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Removing one copy of sr in a ptcD130 background rescues the migration of many ganglionic branches, whereas double mutant embryos exhibit impaired ganglionic branch migration.

    sr155/bnl00857 double mutants exhibit impaired ganglionic branch migration.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    Comments
    Comments

    Strong sr allele.

    Severe sr allele.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (10)