FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ras85DSutor-404
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General Information
Symbol
Dmel\Ras85DSutor-404
Species
D. melanogaster
Name
FlyBase ID
FBal0033981
Feature type
allele
Associated gene
Dmel\Ras85D
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Schnorr and Berg, 1996)
Progenitor genotype
Cytology
Description

5' splice site point mutation in intron 1, which changes the conserved GU to AU. The altered 5' splice site may no longer serve as a docking site for the U1snRNP complex of the spliceosome, and subsequently lead to incomplete RNA splicing.

(Wu, 2000.1.28)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:9,512,152..9,512,152 [-]
Nucleotide change:

G9512152A

Reported nucleotide change:

G?A

Comment:

Mutation in splice donor sequence which changes the conserved GU to AU.

(Wu, 2000.1.28)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ras85DSutor-404/Ras85D05703 transheterozygotes have low viability. Females transheterozygotes with Ras85D05703 lay eggs with a severely disrupted eggshell (patch of chorion instead of dorsal appendages), 25% of eggs hatch and develop to normal larvae. Transheterozygotes with Ras85D05703 exhibit slightly disrupted ommatidial array (small number of fused and misplaced ommatidia).

      (Schnorr and Berg, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Ras85D[+]/Ras85DSutor-404 is a suppressor of visible phenotype of EgfrE1

      (Doyle and Bishop, 1993)
      Other
      Statement
      Reference

      RafSu2, Ras85DSutor-404 has lethal phenotype

      (Li et al., 2000)

      RafSu2, Ras85D[+]/Ras85DSutor-404 has lethal phenotype

      (Li et al., 2000)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Ras85D[+]/Ras85DSutor-404 is a suppressor of eye phenotype of EgfrE1

      (Doyle and Bishop, 1993)

      Ras85DSutor-404 is a suppressor of phenotype of tor11D

      (Doyle and Bishop, 1993)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Strong suppression of the EgfrE1 rough eye phenotype.

      (Doyle and Bishop, 1993)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Maternal and zygotic activity.

      (Doyle and Bishop, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      404-9-1
      (Li et al., 2000)
      Ras1su(tor)404
      (Schnorr and Berg, 1996)
      Ras85DSutor-404
      Su(tor)3-2404
      (Doyle and Bishop, 1993)
      Su(tor)404
      (Li et al., 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)