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General Information
Symbol
Dmel\Ras85DSutor-404
Species
D. melanogaster
Name
FlyBase ID
FBal0033981
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G9512152A

Reported nucleotide change:

G?A

Comment:

Mutation in splice donor sequence which changes the conserved GU to AU.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

5' splice site point mutation in intron 1, which changes the conserved GU to AU. The altered 5' splice site may no longer serve as a docking site for the U1snRNP complex of the spliceosome, and subsequently lead to incomplete RNA splicing.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Ras85DSutor-404/Ras85D05703 transheterozygotes have low viability. Females transheterozygotes with Ras85D05703 lay eggs with a severely disrupted eggshell (patch of chorion instead of dorsal appendages), 25% of eggs hatch and develop to normal larvae. Transheterozygotes with Ras85D05703 exhibit slightly disrupted ommatidial array (small number of fused and misplaced ommatidia).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

Ras85D[+]/Ras85DSutor-404 is a suppressor of visible phenotype of EgfrE1

Other
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference

Ras85DSutor-404 is a suppressor of phenotype of tor11D

Ras85D[+]/Ras85DSutor-404 is a suppressor of eye phenotype of EgfrE1

Additional Comments
Genetic Interactions
Statement
Reference

Strong suppression of the EgfrE1 rough eye phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Maternal and zygotic activity.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Ras1su(tor)404
Ras85DSutor-404
Su(tor)3-2404
Su(tor)404
Name Synonyms
Secondary FlyBase IDs
    References (4)