FlyBase Allele Report: Dmel\Raf[Su2]

General Information

Symbol

Dmel\Raf^Su2

Species

D. melanogaster

Name

FlyBase ID

FBal0039753

Feature type

allele

Associated gene

Dmel\Raf

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Lu et al., 1994)

Progenitor genotype

Raf¹

(Li et al., 2000)

Cytology

Description

Amino acid replacement: P308L. Mutation in the CR1 domain.

(Lu et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:2,341,808..2,341,808 [+]

Nucleotide change:

C2341808T

Amino acid change:

P265L | Raf-PA; P265L | Raf-PE

Reported amino acid change:

P308L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Lu et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Li et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Dsor1^r1, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Raf^Su2, Ras85D^ΔC40B has lethal phenotype

(Li et al., 2000)

Df(2L)C144/+, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Df(2L)TW137/+, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Df(2L)cact-255rv64/+, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Df(2L)net-PMF/+, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Df(2L)sc19-8/+, Raf^Su2 has lethal phenotype

(Li et al., 2000)

+/Df(2R)44CE, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Df(2R)Pu-D17/+, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Df(3L)M21/+, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Df(3R)DG2/+, Raf^Su2 has lethal phenotype

(Li et al., 2000)

+/Df(3R)Delta-BX12, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Raf^Su2, Ras85D^Sutor-404 has lethal phenotype

(Li et al., 2000)

Df(3R)M-Kx1/+, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Df(3R)ME15/+, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Df(3R)T-32/+, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Df(3R)by10/+, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Dsor1[+]/Dsor1^r1, Raf^Su2 has lethal phenotype

(Li et al., 2000)

+/In(2R)bw^VDe2LCy^R, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Raf^Su2, Ras85D[+]/Ras85D^Sutor-404 has lethal phenotype

(Li et al., 2000)

Df(3L)GN24/Src64B^Δ17, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Raf^Su2, T(Y;3)B81/+ has lethal phenotype

(Li et al., 2000)

Raf^Su2, bowl^L26/bowl[+] has lethal phenotype

(Li et al., 2000)

Raf^Su2, bowl^Sutor-85/bowl[+] has lethal phenotype

(Li et al., 2000)

Raf^Su2, ksr[+]/ksr^7M6 has lethal phenotype

(Li et al., 2000)

Raf^Su2, rl[+]/rl¹⁰ has lethal phenotype

(Li et al., 2000)

Df(2L)H20, Raf^Su2 has viable phenotype

(Li et al., 2000)

Raf^Su2, Ras85D[+]/Ras85D^ΔC40B has lethal phenotype

(Li et al., 2000)

Df(3L)vin5/+, Raf^Su2 has visible phenotype

(Li et al., 2000)

Df(3L)vin7/+, Raf^Su2 has visible phenotype

(Li et al., 2000)

Raf^Su2, bowl^L26 has lethal phenotype

(Li et al., 2000)

14-3-3ε^Δ24, Raf^Su2 has lethal phenotype

(Li et al., 2000)

Raf^Su2, bowl^Sutor-85 has lethal phenotype

(Li et al., 2000)

Df(2L)TE29Aa-11/+, Raf^Su2 has partially lethal phenotype

(Li et al., 2000)

Raf^Su2, Src64B^Δ17 has partially lethal - majority die phenotype

(Li et al., 2000)

Df(2R)B5/+, Raf^Su2 has partially lethal phenotype

(Li et al., 2000)

Df(2R)CX1/+, Raf^Su2 has partially lethal phenotype

(Li et al., 2000)

Df(2R)vg-C/+, Raf^Su2 has partially lethal phenotype

(Li et al., 2000)

Df(3L)AC1/+, Raf^Su2 has partially lethal phenotype

(Li et al., 2000)

Df(3L)GN24/+, Raf^Su2 has partially lethal phenotype

(Li et al., 2000)

Df(3L)vin5/+, Raf^Su2 has partially lethal phenotype

(Li et al., 2000)

Df(3L)vin7/+, Raf^Su2 has partially lethal phenotype

(Li et al., 2000)

Raf^Su2, Src64B^Δ17 has visible phenotype

(Li et al., 2000)

Raf^Su2, rl¹⁰ has lethal phenotype

(Li et al., 2000)

Raf^Su2, ksr^7M6 has lethal phenotype

(Li et al., 2000)

14-3-3ε^Δ24/14-3-3epsilon[+], Raf^Su2 has lethal phenotype

(Li et al., 2000)

Phenotype Manifest In

Other

Statement

Reference

Raf^Su2, Src64B^Δ17 has eye phenotype

(Li et al., 2000)

Df(3L)vin5/+, Raf^Su2 has wing phenotype

(Li et al., 2000)

Raf^Su2, Src64B^Δ17 has ommatidium phenotype

(Li et al., 2000)

Df(3L)vin5/+, Raf^Su2 has wing margin phenotype

(Li et al., 2000)

Df(3L)vin7/+, Raf^Su2 has wing phenotype

(Li et al., 2000)

Df(3L)vin7/+, Raf^Su2 has wing margin phenotype

(Li et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

phl^Su2/Y ; Src64B^Δ17/Src64B^Δ17 males show semi-lethality. The surviving males have eyes that are slightly small and rough. About half of phl^Su2/Y ; Df(3L)vin5/+ escapers show wing defects in the posterior part of the wing, showing either notches along the margin or anterior pattern duplications at the expense of posterior pattern elements. These defects are also found in approximately 10% of phl^Su2/Y ; Df(3L)vin7/+ males.

(Li et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

Raf¹

(Lu et al., 1994)

Comments

phl¹ homozygous lethality and hemizygous male eye defect can be partially rescued by one copy of phl^Su2.

(Lu et al., 1994)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Relative suppressor ability: phl^Su3 > phl^Su8 > phl^Su5 > phl^Su2.

(Lu et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Draf^Su2

(Li et al., 2000)

Raf^Su2

Su(D-raf)2

(Lu et al., 1994)

Su(Draf^C110)2

(Li et al., 1998)

phl^Su2

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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