FlyBase Allele Report: Dmel\ash1[B1]

General Information

Symbol

Dmel\ash1^B1

Species

D. melanogaster

Name

FlyBase ID

FBal0039152

Feature type

allele

Associated gene

Dmel\ash1

Associated Insertion(s)

Carried in Construct

Also Known As

ash-1^B1

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q1669term (revision of data in FBrf0233053).

(Locke, 2018.7.13)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:19,593,107..19,593,107 [-]

Nucleotide change:

C19593107T

Amino acid change:

Q1669term | ash1-PB; Q1669term | ash1-PC

Reported amino acid change:

Q1669term

Comment:

The mutation was originally reported as Q1660term based on an outdated version of the ash1 annotation. The mutation relative to the current annotation is Q1669term.

(Locke, 2018.7.13)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\MAPT^R406W.UAS

(Frost et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal segment 6

(Ruhf et al., 2001)

abdominal tergite

(Bi et al., 2022)

Detailed Description

Statement

Reference

ash1^B1/Df(3L)Exel9007 tranheterozygotes are lethal.

(McCracken and Locke, 2016)

ash1^B1/+ has no effect on the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5 or P{hsp26-pt-T}39C-27. ash1^B1/+ suppresses the telomeric position effect (TPE) of P{hsp26-pt-T}39C-31 and P{wA}4-4 in females but not in males.

(Boivin et al., 2003)

Transformation of abdominal segment A6 to A5.

(Ruhf et al., 2001)

Mutation does not affect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ash1^B1 has visible | adult stage | dominant phenotype, enhanceable by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

NOT Enhanced by

Statement

Reference

ash1^B1 has visible | adult stage | dominant phenotype, non-enhanceable by Df(3R)Exel8157/+

(Bi et al., 2022)

Suppressed by

Statement

Reference

ash1^B1 has visible | homeotic phenotype, suppressible by dom¹⁴/dom[+]

(Ruhf et al., 2001)

Suppressor of

Statement

Reference

ash1^B1/ash1[+] is a suppressor of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

ash1^B1/ash1[+] is a suppressor of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

ash1^B1/ash1[+] is a suppressor of increased cell death phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Frost et al., 2014)

NOT Suppressor of

Statement

Reference

ash1^B1 is a non-suppressor of visible phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

Other

Statement

Reference

ash1^B1, corto[+]/corto⁴²⁰ has visible phenotype

(Lopez et al., 2001)

ash1^B1, corto⁴²⁰ has visible phenotype

(Lopez et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

ash1^B1 has abdominal tergite phenotype, enhanceable by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

ash1^B1 has abdominal tergite phenotype, enhanceable by Df(3R)Exel8157/+

(Bi et al., 2022)

NOT Enhanced by

Statement

Reference

ash1^B1 has phenotype, non-enhanceable by lolal^k02512/lolal[+]

(Mishra et al., 2003)

Suppressed by

Statement

Reference

ash1^B1 has abdominal segment 6 phenotype, suppressible by dom¹⁴/dom[+]

(Ruhf et al., 2001)

NOT suppressed by

Statement

Reference

ash1^B1 has phenotype, non-suppressible by lolal^k02512/lolal[+]

(Mishra et al., 2003)

Enhancer of

Statement

Reference

ash1^B1 is an enhancer of eye phenotype of CycE^JP

(Brumby et al., 2002)

NOT Enhancer of

Statement

Reference

ash1^B1/ash1[+] is a non-enhancer of phenotype of lolal^k02512

(Mishra et al., 2003)

Suppressor of

Statement

Reference

ash1^B1/ash1[+] is a suppressor of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

ash1^B1/ash1[+] is a suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

ash1^B1/ash1[+] is a suppressor of neuron phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Frost et al., 2014)

NOT Suppressor of

Statement

Reference

ash1^B1 is a non-suppressor of eye phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

ash1^B1/ash1[+] is a non-suppressor of phenotype of lolal^k02512

(Mishra et al., 2003)

Other

Statement

Reference

ash1^B1, corto[+]/corto⁴²⁰ has posterior crossvein phenotype

(Lopez et al., 2001)

ash1^B1, corto⁴²⁰ has posterior crossvein phenotype

(Lopez et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is ameliorated by combination with a single copy of ash1^B1

(Morimoto et al., 2016)

The addition of heterozygous, ash1^B1 to lolal^k02512/+ animals shows enhancement or suppression.

(Mishra et al., 2003)

ash1^B1 corto⁴²⁰ double heterozygotes show posterior crossvein defects.

(Lopez et al., 2001)

The eye colour of flies carrying w^{4.Ubx.bxd:pbx.N} is reduced if they are also heterozygous for ash1^B1.

(Rozovskaia et al., 1999)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is ameliorated by combination with a single copy of ash1^B1.

(Morimoto et al., 2016)

Heterozygous ash1^B1 suppresses the Scer\GAL4^elav.PU>Hsap\MAPT^{R406W.Scer\UAS}-induced neuronal apoptosis.

(Frost et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5045

ash1^B1/TM6C, cu¹ Sb¹ ca¹

Kyoto

108005

ash1^B1/TM6C, cu¹ Sb¹ ca¹

Notes on Origin

Discoverer

J. Kennison.

(Kassis, 1994)

The chromosome also carries a second site lethal mutation and an enhancer of In(1)w^m4 variegation.

(McCracken and Locke, 2016)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ash-1^B1

(Fauvarque et al., 1995, Gindhart and Kaufman, 1995)

ash1^B1

(Bi et al., 2022, McCracken and Locke, 2016, Frost et al., 2014, Lee and Spradling, 2014, Vasanthi et al., 2013, Hallson et al., 2012, Sultana et al., 2011, Smulders-Srinivasan et al., 2010, Christensen et al., 2008.4.15, Vázquez et al., 2008, Chang et al., 2007, Secombe et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (25)

Report Sections

Open Close