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General Information
Symbol
Dmel\Drp1T26
Species
D. melanogaster
Name
FlyBase ID
FBal0039507
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)22FdT26
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Drp1T26/+ mutants are fully viable.

No hemizygous pupae are recovered.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Suppressor of
Statement
Reference

Drp1[+]/Drp1T26 is a suppressor of visible phenotype of Pink1UAS.Tag:HA, Scer\GAL4GMR.PF

Other
Phenotype Manifest In
Enhancer of
Suppressor of
Statement
Reference

Drp1[+]/Drp1T26 is a suppressor of eye phenotype of Pink1UAS.Tag:HA, Scer\GAL4GMR.PF

Additional Comments
Genetic Interactions
Statement
Reference

Drp1T26/+ in combination with park25/park25 mutants results in lethality. Viability of flies Drp1T26/+ is unaffected in a park25/+ background.

Drp1T26/+ in combination with Pink1B9 hemizygous mutations results in almost complete lethality. The few surviving adults are developmentally delayed and are substantially smaller and short lived than single Pink1B9 hemizygous mutants. Viability of Drp1T26/+ flies is unaffected in a heterozygous Pink1B9/+ background.

The rough eye phenotype of flies expressing Pink1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF is suppressed in the presence of Drp1T26/+ mutation.

Xenogenetic Interactions
Statement
Reference

Drp1T26 enhances the increase in mitochondria length seen when Hsap\MAPTR406W.Scer\UAS is expressed under the control of Scer\GAL4elav.PU. Increased levels of neurotoxicity are also seen.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)