FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pka-C1DN
Open Close
General Information
Symbol
Dmel\Pka-C1DN
Species
D. melanogaster
Name
dominant negative
FlyBase ID
FBal0042697
Feature type
allele
Associated gene
Dmel\Pka-C1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

antimorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    antimorphic allele - genetic evidence

    (Pan and Rubin, 1995)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        No change in wing area is seen in heterozygous Pka-C1DN mutant flies raised at 27[o]C.

        (Cheng et al., 2012)

        Heterozygotes exhibit a dominant phenotype, overgrowth in the costa region of the adult wing. Phenotype is enhanced by a weak loss of function allele and suppressed by increasing the dosage of wild type Pka-C1. Mutant eye phenotype of hhbar3 homozygotes is suppressed when in combination with Pka-C1DN heterozygote, cell death is also suppressed.

        (Pan and Rubin, 1995)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        Pka-C1DN is an enhancer of visible | adult stage phenotype of wdpKO.ΔCDS

        (Takemura et al., 2020)

        Pka-C1DN is an enhancer of abnormal neuroanatomy phenotype of PlexAUAS.Tag:HA, Scer\GAL4elav.PU

        (Yang and Terman, 2012)
        Other
        Statement
        Reference

        Pka-C1[+]/Pka-C1DN, Sema1aUAS.cYa has abnormal neuroanatomy phenotype

        (Yang and Terman, 2012)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        One copy of Pka-C1DN enhances the reduction in L3-L4 intervein area seen in Gprk2KO/Df(3R)Gprk2-del1 mutant flies.

        (Cheng et al., 2012)

        Expression of one copy of Sema-1aScer\UAS.cYa under the control of Scer\GAL4how-24B in embryos that are also heterozygous for Pka-C1DN results in axon guidance defects in the ISNb and SNa nerves, resulting in reduced muscle innervation.

        The axon guidance defects in the central nervous system which are caused by expression of plexAScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav.PU are enhanced if the embryos carry Pka-C1DN.

        (Yang and Terman, 2012)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (2)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (5)
        Reported As
        Symbol Synonym
        Dc0DN
        (Huang et al., 2025)
        PKAC1DN
        (Graves et al., 2015)
        Pka-C1DN
        (Takemura et al., 2020)
        pka-c1DN
        (Cheng et al., 2012)
        Name Synonyms
        dominant negative
        (Pan and Rubin, 1995)
        Secondary FlyBase IDs
          References (7)