FlyBase Allele Report: Dmel\PlexA[UAS.Tag:HA]

General Information

Symbol

Dmel\PlexA^UAS.Tag:HA

Species

D. melanogaster

Name

FlyBase ID

FBal0137117

Feature type

allele

Associated gene

Dmel\PlexA

Associated Insertion(s)

Carried in Construct

P{UAS-PlexA.HA}

Also Known As

UAS-HA-PlexA

Key Links

Transgenic product class

wild_type

(Terman et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Terman et al., 2002)

Mutagen

in vitro construct

(Terman et al., 2002, Terman et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-PlexA.HA}

Cytology

Description

UAS regulatory sequences drive expression of PlexA tagged with Tag:HA.

(Terman et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

PlexA

Tagged with

Tag:HA

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^elav.PU

(Yang and Terman, 2012)

abnormal neuroanatomy | adult stage, with Scer\GAL4^VGlut1-OK371

(Syed et al., 2016)

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^elav.PU

(Cho et al., 2012)

visible, with Scer\GAL4^B11-98

(Hung et al., 2010)

Phenotype Manifest In

actin-based cell projection | oogenesis, with Scer\GAL4^NP1624

(Stedden et al., 2019)

axon | adult stage, with Scer\GAL4^VGlut1-OK371

(Syed et al., 2016)

follicle cell, with Scer\GAL4^NP1624

(Stedden et al., 2019)

larval longitudinal connective, with Scer\GAL4^elav.PU

(Yang and Terman, 2012)

larval longitudinal connective | embryonic stage, with Scer\GAL4^elav.PU

(Cho et al., 2012)

macrochaeta, with Scer\GAL4^B11-98

(Hung et al., 2010)

motor neuron | adult stage, with Scer\GAL4^VGlut1-OK371

(Syed et al., 2016)

muscle cell of leg muscle of leg, with Scer\GAL4^VGlut1-OK371

(Syed et al., 2016)

wing disc, with Scer\GAL4^en-e16E

(Sweeney et al., 2011)

Detailed Description

Statement

Reference

Expressing PlexA^UAS.Tag:HA in the entire follicular epithelium under the control of Scer\GAL4^NP1624 leads to a small decrease in basal protrusions, as compared to controls.

(Stedden et al., 2019)

Expression of PlexA^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^VGlut-OK371 results in defects in axonal branching in the motoneurons innervating leg muscles in proximal femur (excessive defasciculation, ectopic branches exiting the main nerve) and distal tibia (reduced defasciculation).

(Syed et al., 2016)

Expression of plexA^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PU results in a low, but significant, frequency of longitudinal tracts crossing the midline.

(Cho et al., 2012)

Expression of plexA^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PU results in axon guidance defects in the central nervous system (longitudinal connectives are disrupted).

(Yang and Terman, 2012)

Expression of plexA^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^en-e16E disrupts wing disc compartment morphology.

(Sweeney et al., 2011)

Expression of two copies of plexA^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^B11-98 results in branched bristles.

(Hung et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by trol^UAS.RG, Scer\GAL4^elav.PU

(Cho et al., 2012)

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, enhanceable by 14-3-3ε^j2B10

(Yang and Terman, 2012)

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, enhanceable by Pka-C1^DN

(Yang and Terman, 2012)

Suppressed by

Statement

Reference

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, suppressible by Ras64B^Val14.UAS, Scer\GAL4^elav.PU

(Yang and Terman, 2012)

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, suppressible by if^UAS.cUa, Scer\GAL4^elav.PU

(Yang and Terman, 2012)

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, suppressible by 14-3-3ε^UAS.Tag:FLAG, Scer\GAL4^elav.PU

(Yang and Terman, 2012)

PlexA^UAS.Tag:HA, Scer\GAL4^B11-98 has visible phenotype, suppressible by Mical^unspecified/Mical^unspecified

(Hung et al., 2010)

NOT suppressed by

Statement

Reference

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, non-suppressible by Ras85D^V12.UAS, Scer\GAL4^elav.PU

(Yang and Terman, 2012)

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, non-suppressible by mew^UAS.cWa, Scer\GAL4^elav.PU

(Yang and Terman, 2012)

Suppressor of

Statement

Reference

PlexA^UAS.Tag:HA/Scer\GAL4^elav-C155 is a suppressor of abnormal neuroanatomy phenotype of PlexB^KG00878

(Ayoob et al., 2006)

PlexA^UAS.Tag:HA/Scer\GAL4^elav-C155 is a suppressor of partially lethal - majority die phenotype of PlexB^KG00878

(Ayoob et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

PlexA^UAS.Tag:HA, Scer\GAL4^NP1624 has follicle cell phenotype, enhanceable by Sema5c^UAS.EGFP, Scer\GAL4^NP1624

(Stedden et al., 2019)

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has larval longitudinal connective | embryonic stage phenotype, enhanceable by trol^UAS.RG, Scer\GAL4^elav.PU

(Cho et al., 2012)

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has larval central nervous system phenotype, enhanceable by 14-3-3ε^j2B10

(Yang and Terman, 2012)

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has larval central nervous system phenotype, enhanceable by Pka-C1^DN

(Yang and Terman, 2012)

Suppressed by

Statement

Reference

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has larval central nervous system phenotype, suppressible by 14-3-3ε^UAS.Tag:FLAG, Scer\GAL4^elav.PU

(Yang and Terman, 2012)

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has larval central nervous system phenotype, suppressible by Ras64B^Val14.UAS, Scer\GAL4^elav.PU

(Yang and Terman, 2012)

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has larval central nervous system phenotype, suppressible by if^UAS.cUa, Scer\GAL4^elav.PU

(Yang and Terman, 2012)

PlexA^UAS.Tag:HA, Scer\GAL4^B11-98 has macrochaeta phenotype, suppressible by Mical^unspecified/Mical^unspecified

(Hung et al., 2010)

NOT suppressed by

Statement

Reference

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has larval central nervous system phenotype, non-suppressible by Ras85D^V12.UAS, Scer\GAL4^elav.PU

(Yang and Terman, 2012)

PlexA^UAS.Tag:HA, Scer\GAL4^elav.PU has larval central nervous system phenotype, non-suppressible by mew^UAS.cWa, Scer\GAL4^elav.PU

(Yang and Terman, 2012)

Enhancer of

Statement

Reference

PlexA^UAS.Tag:HA, Scer\GAL4^NP1624 is an enhancer of follicle cell phenotype of Scer\GAL4^NP1624, Sema5c^UAS.EGFP

(Stedden et al., 2019)

PlexA^UAS.Tag:HA, Scer\GAL4^NP1624 is an enhancer of actin-based cell projection | oogenesis phenotype of Scer\GAL4^NP1624, Sema5c^UAS.EGFP

(Stedden et al., 2019)

Suppressor of

Statement

Reference

PlexA^UAS.Tag:HA/Scer\GAL4^elav-C155 is a suppressor of larval intersegmental nerve phenotype of PlexB^KG00878

(Ayoob et al., 2006)

PlexA^UAS.Tag:HA/Scer\GAL4^elav-C155 is a suppressor of larval segmental nerve branch SNa of A1-7 phenotype of PlexB^KG00878

(Ayoob et al., 2006)

PlexA^UAS.Tag:HA/Scer\GAL4^elav-C155 is a suppressor of medial longitudinal fascicle phenotype of PlexB^KG00878

(Ayoob et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of trol^Scer\UAS.RG significantly enhances the aberrant midline crossing phenotype seen in longitudinal tracts of embryos expressing plexA^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PU.

(Cho et al., 2012)

The axon guidance defects in the central nervous system which are caused by expression of plexA^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PU are enhanced if the embryos carry 14-3-3ε^j2B10 and are suppressed if the embryos also co-express 14-3-3ε^{Scer\UAS.T:Zzzz\FLAG}.

The axon guidance defects in the central nervous system which are caused by expression of plexA^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PU are suppressed if the embryos also co-express either Ras64B^{Val14.Scer\UAS} or if^Scer\UAS.cUa, but are unaffected if the embryos also co-express either Ras85D^V12.Scer\UAS or mew^Scer\UAS.cWa.

(Yang and Terman, 2012)

The branched bristle phenotype caused by expression of two copies of plexA^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^B11-98 is suppressed if the flies are also homozygous for Mical^unspecified.

(Hung et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

PlexA^{Scer\UAS.T:Ivir\HA1}

PlexA^UAS.Tag:HA

plexA^{Scer\UAS.T:Ivir\HA1}

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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