FlyBase Allele Report: Dmel\wdp[KO.ΔCDS]

General Information

Symbol

Dmel\wdp^KO.ΔCDS

Species

D. melanogaster

Name

FlyBase ID

FBal0359845

Feature type

allele

Associated gene

Dmel\wdp

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

loss of function allele

(Takemura et al., 2020)

Mutagen

CRISPR/Cas9

(Takemura et al., 2020)

Progenitor genotype

Cytology

Description

Most of the coding sequence of wdp is deleted (2kb).

(Takemura et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

2R:22,298,923..22,300,918 [-]

Comment:

A 1996bp deletion (and 2 base insertion) removes most of the wdp coding sequence.

Inserted_sequence:

(Takemura et al., 2020)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | oogenesis | progressive

(Koh et al., 2023)

fertile

(Koh et al., 2023, Takemura et al., 2020)

viable

(Koh et al., 2023, Takemura et al., 2020)

visible | adult stage

(Takemura et al., 2020)

Phenotype Manifest In

mechanosensory chaeta | adult stage | increased number

(Takemura et al., 2020)

ovary

(Koh et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

wdp^KO.ΔCDS has visible | adult stage phenotype, enhanceable by Pka-C1^DN

(Takemura et al., 2020)

Suppressed by

Statement

Reference

wdp^KO.ΔCDS has visible | adult stage phenotype, suppressible | partially by hh[+]/hh^AC

(Takemura et al., 2020)

Enhancer of

Statement

Reference

wdp^KO.ΔCDS/wdp^KO.ΔCDS is an enhancer of visible | adult stage phenotype of dally^gem

(Koh et al., 2023)

Other

Statement

Reference

dally^gem, wdp^KO.ΔCDS has visible | adult stage phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has female sterile | adult stage phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has increased size | oogenesis | progressive phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has partially lethal - majority die phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has visible | adult stage phenotype

(Koh et al., 2023)

Phenotype Manifest In

Enhanced by

Statement

Reference

wdp^KO.ΔCDS has mechanosensory chaeta | adult stage | increased number phenotype, enhanceable by Pka-C1^DN

(Takemura et al., 2020)

Suppressed by

Statement

Reference

wdp^KO.ΔCDS has mechanosensory chaeta | increased number | adult stage phenotype, suppressible | partially by hh[+]/hh^AC

(Takemura et al., 2020)

Enhancer of

Statement

Reference

wdp^KO.ΔCDS/wdp^KO.ΔCDS is an enhancer of male genitalia | absent phenotype of dally^gem

(Koh et al., 2023)

wdp^KO.ΔCDS/wdp^KO.ΔCDS is an enhancer of longitudinal vein phenotype of dally^gem

(Koh et al., 2023)

NOT Enhancer of

Statement

Reference

wdp^KO.ΔCDS/wdp^KO.ΔCDS is a non-enhancer of wing margin phenotype of dally^gem

(Koh et al., 2023)

NOT Suppressor of

Statement

Reference

wdp^KO.ΔCDS/wdp^KO.ΔCDS is a non-suppressor of wing margin phenotype of dally^gem

(Koh et al., 2023)

Other

Statement

Reference

dally^gem, wdp^KO.ΔCDS has wing phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has wing phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has alar lobe phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has ovary phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has wing margin phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has egg | increased number phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has egg chamber | absent phenotype

(Koh et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

wdp^KO.ΔCDS

(Takemura et al., 2020)

wdp^KO

(Koh et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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