FlyBase Allele Report: Dmel\Sulf1[ΔP1]

General Information

Symbol

Dmel\Sulf1^ΔP1

Species

D. melanogaster

Name

FlyBase ID

FBal0248455

Feature type

allele

Associated gene

Dmel\Sulf1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Kleinschmit et al., 2010)

Mutagen

Delta2-3 transposase

(Kleinschmit et al., 2010)

Progenitor genotype

P{GT1}Sulf1^GT-000656

(Kleinschmit et al., 2010)

Cytology

Description

Imprecise excision of the progenitor insertion, P{GT1}Sulf1^GT-000656 results in a deletion which removes exons 4-10 of Sulf1 with loss of most of the protein coding sequence including part of the catalytic domain of Sulf1.

(Kleinschmit et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The wings of mutant adults are larger than normal and show defects in apposition of the two wing surfaces. There is a mild broadening of the spacing between the L3 and L4 veins compared to wild type. Supernumerary chemosensory and mechanosensory bristles are observed on the anterior wing margin.

Wings carrying homozygous clones in the anterior compartment show broadening of the spacing between veins L3 and L4 and also show defects in the positioning of the L2 vein. Wings carrying homozygous clones in the posterior compartment of the wing show a narrowing of the spacing between veins L3 and L4 and defects in the positioning of wing vein L2.

(Wojcinski et al., 2011)

Sulf1^ΔP1 and Sulf1^ΔP1/Df(3R)sbd26 mutant adults both display defects in wing margin bristles. An increase in the number of chemosensory and mechanosensory bristles on the anterior wing margin is evident. Ectopic mechanosensory bristles which have shifted more posterior to their normal position are also observed.

Sulf1^ΔP1 third instar larval wing discs exhibit an increase in the number of sensory organ precursors. An irregular, borader distribution of the SOPs is observed in the disc.

(Kleinschmit et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Sulf1^KO.Cherry/Sulf1^ΔP1 has increased occurrence of cell division | adult stage phenotype, suppressible by Scer\GAL4^NP6267/Stat92E^RNAi.UAS

(Takemura and Nakato, 2017)

Sulf1^KO.Cherry/Sulf1^ΔP1 has increased occurrence of cell division | adult stage phenotype, suppressible by Scer\GAL4^NP6267/Egfr^DN.UAS.cBa

(Takemura and Nakato, 2017)

Sulf1^KO.Cherry/Sulf1^ΔP1 has increased occurrence of cell division | adult stage phenotype, suppressible by Scer\GAL4^NP6267/ptc^UAS.cJa

(Takemura and Nakato, 2017)

Sulf1^ΔP1 has visible phenotype, suppressible by Hs6st^d770

(Kleinschmit et al., 2010)

Sulf1^ΔP1 has visible phenotype, suppressible by dally^gem

(Kleinschmit et al., 2010)

Other

Statement

Reference

Sulf1^ΔP1, wdp^KO.ΔCDS has partially lethal - majority die phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has visible | adult stage phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has female sterile | adult stage phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has increased size | oogenesis | progressive phenotype

(Koh et al., 2023)

Phenotype Manifest In

Suppressed by

Statement

Reference

Sulf1^KO.Cherry/Sulf1^ΔP1 has adult posterior midgut epithelium phenotype, suppressible by Scer\GAL4^NP6267/Egfr^DN.UAS.cBa

(Takemura and Nakato, 2017)

Sulf1^KO.Cherry/Sulf1^ΔP1 has adult posterior midgut epithelium phenotype, suppressible by Scer\GAL4^NP6267/ptc^UAS.cJa

(Takemura and Nakato, 2017)

Sulf1^KO.Cherry/Sulf1^ΔP1 has adult posterior midgut epithelium phenotype, suppressible by Scer\GAL4^NP6267/Stat92E^RNAi.UAS

(Takemura and Nakato, 2017)

Sulf1^ΔP1 has anterior wing margin phenotype, suppressible by Hs6st^d770

(Kleinschmit et al., 2010)

Sulf1^ΔP1 has wing margin bristle | increased number phenotype, suppressible by Hs6st^d770

(Kleinschmit et al., 2010)

Sulf1^ΔP1 has anterior wing margin phenotype, suppressible by dally^gem

(Kleinschmit et al., 2010)

Sulf1^ΔP1 has wing margin bristle | increased number phenotype, suppressible by dally^gem

(Kleinschmit et al., 2010)

Other

Statement

Reference

Sulf1^ΔP1, wdp^KO.ΔCDS has wing phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has alar lobe phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has ovary phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has wing margin phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has egg | increased number phenotype

(Koh et al., 2023)

Sulf1^ΔP1, wdp^KO.ΔCDS has egg chamber | absent phenotype

(Koh et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

The increased division of intestinal stem cells in the adult posterior midgut during normal homeostasis characteristic for Sulf1^KO;Cherry/Sulf1^ΔP1 mutants can be suppressed by expression of any of the following: Stat92E^{dsRNA.Scer\UAS}, Egfr^{DN.Scer\UAS.cBa} or ptc^Scer\UAS.cJa under the control of Scer\GAL4^NP6267 (using tub-Gal80[ts] to limit the time of expression to adulthood).

(Takemura and Nakato, 2017)

Hs6st^d770 suppresses the increased chemosensory bristle phenotype observed at the anterior dorsal wing margin of Sulf1^ΔP1 mutant animals.

dally^gem, Sulf1^ΔP1 mutant animals display the same reduced number of chemosensory and mechanosensory bristles at the anterior dorsal wing margin as dally^gem single mutants.

(Kleinschmit et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Sulf1^P1

(Takemura and Nakato, 2017)

Sulf1^ΔP1

(Koh et al., 2023, Kleinschmit et al., 2010)

sulf1^ΔP1

(Wojcinski et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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