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General Information
Symbol
Dmel\fru0-1
Species
D. melanogaster
Name
FlyBase ID
FBal0043077
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
fru2
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion between the 5' exons of the P3 and P4 promoters.

Insertion lies between the P1 promoter and the common coding region.

Insertion components
P{wAR}fru0-1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

fru0-1/frusat males exhibit reduced midline crossing of ppk23- expressing axons.

fru0-1/fruNP0021 males exhibit reduced courtship activity and copulation success.

Only 10% of the expected number of fru0-1/Df(3R)fruw24 adults are found compared to control siblings. 7% of fru0-1/fruw9 males are fertile. 24% of fru0-1/fru4-40 males are fertile. 33% of fru0-1/frusat15 males are fertile (this may reflect genetic background effects). 93% of fru0-1/fruM5 males are fertile. 23% of fru0-1/fru3 males are fertile. 25% of fru0-1/fru4 males are fertile. Male-female courtship as measured by wing extension index (WEI) is almost completely abolished in fru0-1/fruw9, fru0-1/fruw12, fru0-1/Df(3R)fruw24 or fru0-1/fruw27 males. fru0-1/fruw9, fru0-1/fruw12 or fru0-1/fru4-40 males show substantial chaining. Homozygotes develop a nearly wild-type muscle of Lawrence.

The numbers of serotonergic-abdominal ganglion neurons and their projections in mutant adult males appear normal or nearly so (in terms of 5-HT expression).

fru0-1/fru0-1 and fru0-1/fru1 males show longer than normal mating-initiation latencies compared to heterozygous controls when mated to a single virgin wild-type female. The mating duration is not significantly different from wild type.

The density of varicosities of the sAbg neurons which are associated with the reproductive organs is nearly normal in fru0-1 males.

Males are more stimulated to court females than fru3 or fru4. All males that exhibit any courtship do exhibit tapping behaviour (tapping of the female with the forelegs). Males, when presented with both sexes simultaneously, will show a courtship bias toward females. Mutant females are courted by wild-type males at normal levels.

A normal size muscle of Lawrence (MOL) often forms in homozygous males. There are slightly more adult muscle nuclei in MOL-position fibres than medial fibres, but these fibres still have significantly fewer nuclei than wild-type male MOL fibres. The number of myoblasts in unaffected.

Homozygous males form courtship chains and behaviourally sterile: failure to curl abdomen in attempted copulation. Some males are fertile and have no 'muscle of Lawrence' (MOL) at all or have an intermediate MOL phenotype: slight thickening or slightly altered insertion sites of the longitudinal muscles. Male heterozygotes with In(3R)fru formed courtship chains but were fully fertile and had an abnormal MOL.

Homozygous males appear normal in size and mobility. Homozygous males show chain behaviour and show incomplete penetrance of fru-like sterility. Heterozygotes never form courtship chains and are fully fertile. fru1/fru0-1 males show chain behaviour, although not as intensely as either fru1 or fru0-1 homozygotes, but are essentially normal in fertility.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (23)