FlyBase Allele Report: Dmel\apt[k15608]

General Information

Symbol

Dmel\apt^k15608

Species

D. melanogaster

Name

FlyBase ID

FBal0043423

Feature type

allele

Associated gene

Dmel\apt

Associated Insertion(s)

P{lacW}apt^k15608

Carried in Construct

Also Known As

l(2)k15608, tdf^P2, apt^p2, k15608

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Eulenberg and Schuh, 1997)

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{lacW}apt^k15608

Cytology

Description

P{lacW} insertion 167bp downstream of the putative transcription start site.

(Eulenberg and Schuh, 1997)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(2R)BSC659)

(Kahsai and Cook, 2018)

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

embryonic/larval tracheal section

(Eulenberg and Schuh, 1997)

Detailed Description

Statement

Reference

Stereotypic outgrowth of tracheal branches is severely disrupted in mutant embryos. Mutants show variable tracheal defects.

(Eulenberg and Schuh, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

apt^k15608 is a non-enhancer of abnormal neuroanatomy phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Suppressor of

Statement

Reference

apt[+]/apt^k15608 is a suppressor | partially of decreased size | somatic clone | adult stage phenotype of Scer\GAL4^rn-GAL4, egr^UAS.cMa

(Harris et al., 2020)

apt[+]/apt^k15608 is a suppressor | partially of visible | somatic clone | adult stage phenotype of Scer\GAL4^rn-GAL4, egr^UAS.cMa

(Harris et al., 2020)

apt[+]/apt^k15608 is a suppressor | partially of decreased size | somatic clone | adult stage phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

apt[+]/apt^k15608 is a suppressor | partially of visible | somatic clone | adult stage phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

apt[+]/apt^k15608 is a suppressor of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

NOT Suppressor of

Statement

Reference

apt^k15608 is a non-suppressor of abnormal neuroanatomy phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Phenotype Manifest In

Suppressor of

Statement

Reference

apt[+]/apt^k15608 is a suppressor | partially of wing | somatic clone phenotype of Scer\GAL4^rn-GAL4, egr^UAS.cMa

(Harris et al., 2020)

apt[+]/apt^k15608 is a suppressor | partially of wing | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, rpr^{13xlexAop.cHa}

(Harris et al., 2020)

apt[+]/apt^k15608 is a suppressor of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

apt⁰⁶³⁶⁹

(BDGP Project Members, 1994-1999)

apt⁰⁹⁰⁴⁹

(BDGP Project Members, 1994-1999)

Fails to complement

apt⁰³⁰⁴¹

(BDGP Project Members, 1994-1999)

apt⁰⁷⁰¹⁰

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

10455

y¹ w^67c23; P{lacW}apt^k15608/CyO

Kyoto

111110

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{lacW}apt^k15608 /CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

Comments

Complements: Dcp-1⁰²¹²¹. Complements: Dcp-1⁰²¹³². Complements: retn⁰⁵⁰⁹⁶.

(BDGP Project Members, 1994-1999)

Mobilisation of the P{lacW} insertion reverts the tracheal phenotype demonstrating the insertion is responsible for the mutant phenotype.

(Eulenberg and Schuh, 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

apt¹⁵⁶⁰⁸

(Mutsuddi et al., 2004)

apt^K15608

(Harris et al., 2020)

apt^P2

(Liu et al., 2014)

apt^k15608

(Kahsai and Cook, 2018, Christensen et al., 2008.12.28)

apt^p2

(Wang et al., 2017)

l(2)03041^k15608

l(2)k15608

(Liu et al., 2003, Spradling et al., 1999, Eulenberg and Schuh, 1997)

tdf^P2

(Liu et al., 2003, Eulenberg and Schuh, 1997)

tdf^k15608

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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