FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\wgPE2
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General Information
Symbol
Dmel\wgPE2
Species
D. melanogaster
Name
FlyBase ID
FBal0046806
Feature type
allele
Associated gene
Dmel\wg
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bejsovec and Wieschaus, 1995)
Progenitor genotype
Cytology
Description

Missense mutation in a highly conserved region at the carboxy terminal end of the protein. Amino acid replacement: V453E.

(Bejsovec and Wieschaus, 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:7,315,137..7,315,137 [+]
Nucleotide change:

T7315137A

Amino acid change:

V453E | wg-PA

Reported amino acid change:

V453E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Bejsovec and Wieschaus, 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos show the denticle diversity characteristic of a wild-type denticle belt, but have little naked cuticle separating the belts.

      (Bejsovec and Chao, 2012)

      Mutant embryos have normal segmental patterning of the denticle rows, but show loss of the intervening naked cuticle.

      (Jones and Bejsovec, 2005)

      Embryos exhibit denticle diversity and no naked cuticle.

      (Bejsovec and Wieschaus, 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      wgPE2 has phenotype, enhanceable by dallyhs.PJ

      (Moline et al., 2000)

      wgPE2 has phenotype, enhanceable by fz2UAS.cZa/dallyhs.PJ/Scer\GAL4e22c

      (Moline et al., 2000)
      Suppressed by
      Statement
      Reference

      wgPE2 has embryonic/first instar larval cuticle phenotype, suppressible by tumAR2

      (Jones and Bejsovec, 2005)

      wgPE2 has phenotype, suppressible by dally06464

      (Moline et al., 2000)

      wgPE2 has phenotype, suppressible by sgl05007

      (Moline et al., 2000)

      wgPE2 has phenotype, suppressible by Scer\GAL4prd.RG1/fz2UAS.cZa

      (Moline et al., 2000)

      wgPE2 has phenotype, suppressible by fz2UAS.cZa/Scer\GAL4e22c

      (Moline et al., 2000)
      NOT suppressed by
      Statement
      Reference

      wgPE2 has phenotype, non-suppressible by fzUAS.cZa/Scer\GAL4e22c

      (Moline et al., 2000)

      wgPE2 has phenotype, non-suppressible by Scer\GAL4prd.RG1/fzUAS.cZa

      (Moline et al., 2000)
      Other
      Statement
      Reference

      ckKT9, wgPE2 has denticle phenotype

      (Bejsovec and Chao, 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Denticles in anterior rows of wgPE2 ckKT9 embryos are pointed and hooked, but larger denticles in posterior rows remain rounded and appear fragmented, particularly along the dorsolateral edge of the denticle field.

      (Bejsovec and Chao, 2012)

      Some naked cuticle is restored in wgPE2 RacGAP50CAR2 double mutant embryos.

      (Jones and Bejsovec, 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      wgPE2 mutation phenocopies the wgl-12 temperature-shift embryos exactly.

      (Bejsovec and Wieschaus, 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      wgPE2
      (Rizzo and Bejsovec, 2017, Bejsovec and Chao, 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)