FlyBase Allele Report: Dmel\aos[257]

General Information

Symbol

Dmel\aos²⁵⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0049597

Feature type

allele

Associated gene

Dmel\aos

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Okabe, 1998.10.3, Okabe et al., 1996)

hypomorphic allele - genetic evidence

(Sawamoto et al., 1996)

Mutagen

Delta2-3 transposase

(Okabe et al., 1996)

P-element activity

(Sawamoto et al., 1996)

Progenitor genotype

aos^p2

(Okabe et al., 1996, Sawamoto et al., 1996)

Cytology

Description

Deleted for almost entire first exon of argos, including the translation initiation site.

(Okabe, 1998.10.3)

Imprecise excision of the P{lacW} insertion of argos^p2 causing deletion of the first exon of argos (which included the ATG codon) and the signal peptide.

(Okabe et al., 1996)

Imprecise excision of the P{lacW} insertion.

(Sawamoto et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased occurrence of cell division | larval stage

(Sawamoto et al., 1996)

visible

(Okabe et al., 1996)

visible (with aos^Δ7)

(Zartman et al., 2009)

Phenotype Manifest In

abdominal 1 lateral pentascolopidial chordotonal organ lch5

(Okabe et al., 1996)

abdominal 2 lateral pentascolopidial chordotonal organ lch5

(Okabe et al., 1996)

abdominal 3 lateral pentascolopidial chordotonal organ lch5

(Okabe et al., 1996)

abdominal 4 lateral pentascolopidial chordotonal organ lch5

(Okabe et al., 1996)

abdominal 5 lateral pentascolopidial chordotonal organ lch5

(Okabe et al., 1996)

abdominal 6 lateral pentascolopidial chordotonal organ lch5

(Okabe et al., 1996)

abdominal 7 lateral pentascolopidial chordotonal organ lch5

(Okabe et al., 1996)

adult optic lobe

(Sawamoto et al., 1996)

dorsal appendage | maternal effect (with aos^p1)

(Zartman et al., 2009)

eye (with aos^Δ7)

(Zartman et al., 2009)

eye | posterior

(Sawamoto et al., 1996)

larval brain | embryonic stage

(Okabe et al., 1996)

mesothoracic dorsal triscolopidial chordotonal organ dch3

(Okabe et al., 1996)

ommatidium

(Sawamoto et al., 1996)

retina & axon

(Sawamoto et al., 1996)

visual primordium

(Sawamoto et al., 1996)

Detailed Description

Statement

Reference

argos^Δ7/argos²⁵⁷ flies have blisters in the eye.

Only 3% of eggs derived from argos²⁵⁷/argos^p1 have defects in dorsal appendage morphology.

(Zartman et al., 2009)

Homozygotes exhibit failure of head involution. The PNS exhibits an increase in the number of Ch organs. rho⁶ argos²⁵⁷ double mutants exhibit the same phenotype as the rho⁶ single mutant: loss of two of five Ch organs at LCh5 and one ventral Ch organ in all abdominal segments.

(Okabe et al., 1996)

Regular ommatidial array is disrupted and posterior region of the eye is blistered.

(Sawamoto et al., 1996)

In embryos, the optic lobe primordium does not form a complete circle after invagination, and can be mislocated at the dorsal surface of the brain. In larvae, the morphology of the outer optic anlagen is disorganized. Optic lobes can be fused at the dorsal surface. Proliferating cells in the inner proliferation center decrease in number. Retinal axons do not innervate the lamina properly.

(Sawamoto et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

aos²⁵⁷ has phenotype, suppressible by Dsor1^Gp158/Dsor1[+]

(Sawamoto et al., 1996)

aos²⁵⁷ has phenotype, suppressible by Ras85D^e2F/Ras85D[+]

(Sawamoto et al., 1996)

aos²⁵⁷ has phenotype, suppressible by S^X155/S[+]

(Sawamoto et al., 1996)

aos²⁵⁷ has phenotype, suppressible by Raf^raf-1/phl[+]

(Sawamoto et al., 1996)

aos²⁵⁷ has retina & axon phenotype, suppressible by S^X155

(Sawamoto et al., 1996)

NOT Suppressor of

Statement

Reference

aos²⁵⁷ is a non-suppressor of phenotype of arm³

(Cox et al., 2000)

Other

Statement

Reference

aos²⁵⁷, sty²⁵⁴ has photoreceptor neuron phenotype

(Kramer et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Massive neuronal differentiation occurs in sty²⁵⁴, argos²⁵⁷ double mutants.

(Kramer et al., 1999)

Decrease in argos gene dosage fails to affect the multiple R7 phenotype of Ras64B^V12.sev or restore the production of R7 cells in sev¹⁴ mutants.

(Sawamoto et al., 1996)

The retinal axon phenotype can be suppressed by S^X155.

(Sawamoto et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

aos^Δ7

(Zartman et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

aos²⁵⁷

(Ogura et al., 2018, Iwanami et al., 2005, Yagi and Hayashi, 1997)

argos²⁵⁷

(Zartman et al., 2009)

gil²⁵⁷

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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