Open Close
General Information
Symbol
Dmel\sty254
Species
D. melanogaster
Name
FlyBase ID
FBal0086312
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
spry254
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotides 2237 to 2243 are replaced by TA, causing a frameshift that adds 134 new residues.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Escapers of lethality show a disorganized eye phenotype. Majority of ommatidia have extra R7 cells, generated by transformation of cone cells. Some of the extra photoreceptors resemble outer (R1-R6) photoreceptor neurons. Mystery cells assume R3/R4 fates. In heterozygous condition, 1-7% of ommatidia show an extra R7 cell or an occasional gain or loss of an outer photoreceptor cell. In embryos, 37% of hemisegments show an extra chordotonal organ in the lateral cluster. In clones in the eye the ommatidial phenotype changes abruptly at the boundary, indicating that the mutant phenotype is cell autonomous. There is no absolute requirement for sty+ in any of the photoreceptor neurons, and sty+ can function non-autonomously to prevent cone cells from differentiating as R7 photoreceptor neurons. The requirement for sty+ function is mainly cell autonomous in the cells that differentiate as extra R7 cells.

Pupal lethal when hemizygous. The number of tracheal branches emanating from the dorsal and ganglionic branches is higher than normal in homozygous embryos.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

sty254 has phenotype, non-enhanceable by sev14

Suppressed by
Statement
Reference

sty254 has photoreceptor cell R7 phenotype, suppressible by sina2

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

No R7 cells form in sty254, sina2 double mutant ommatidia. Massive neuronal differentiation occurs in sty254, argos257 double mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: Dominant suppressor of the rough eye phenotype caused by ectopic expression of svp in photoreceptors R2 and R5.

Comments
Comments

Amorph or strong hypomorph.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)