FlyBase Allele Report: Dmel\Diap1[7]

General Information

Symbol

Dmel\Diap1⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0050597

Feature type

allele

Associated gene

Dmel\Diap1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Lisi et al., 2000)

Mutagen

Progenitor genotype

Cytology

Description

In frame deletion ending at D272, in the BIR domain, which deletes the first half of BIR2, but leaves BIR1 and the ring domain intact.

(Lisi et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:16,039,173..16,039,601 [-]

Comment:

Mutation is an in-frame deletion that begins at P130 and ends at D272. The deletion removes part of the second BIR domain but leaves the first BIR domain and the RING domain intact.

(Lisi et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | conditional

(Jassim et al., 2003)

lethal | recessive

(Lisi et al., 2000)

viable (with Diap1^21-2s)

(Geisbrecht and Montell, 2004)

Phenotype Manifest In

border follicle cell (with Diap1^21-2s)

(Geisbrecht and Montell, 2004)

embryo

(Lisi et al., 2000)

eye | conditional

(Jassim et al., 2003)

Detailed Description

Statement

Reference

11% of th⁷/th^21-2s egg chambers have border follicle cell migration defects.

(Geisbrecht and Montell, 2004)

When heterozygous mutants are UV irradiated a complete ablation of the eye is seen due to an increase in apoptotic cell death. This is a lot stronger than the phenotype seen in irradiated wild-type flies.

(Jassim et al., 2003)

Embryos show increased cell death as assessed by TUNEL staining. The onset of this apoptosis appears several hours after development arrests.

(Lisi et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Diap1⁷ has increased cell death | conditional phenotype, suppressible by BacA\p35^GMR.PH

(Jassim et al., 2003)

Enhancer of

Statement

Reference

Diap1⁷ is an enhancer of abnormal cell death phenotype of rpr^GMR.PW

(Lisi et al., 2000)

Diap1⁷ is an enhancer of abnormal cell death phenotype of hid^GMR.PG

(Lisi et al., 2000)

Diap1⁷ is an enhancer of abnormal cell death phenotype of grim^GMR.PC

(Lisi et al., 2000)

Phenotype Manifest In

Suppressed by

Statement

Reference

Diap1⁷ has eye | conditional phenotype, suppressible by BacA\p35^GMR.PH

(Jassim et al., 2003)

Enhancer of

Statement

Reference

Diap1⁷ is an enhancer of eye phenotype of rpr^GMR.PW

(Lisi et al., 2000)

Diap1⁷ is an enhancer of eye phenotype of hid^GMR.PG

(Lisi et al., 2000, Hay et al., 1995)

Diap1⁷ is an enhancer of eye phenotype of grim^GMR.PC

(Lisi et al., 2000)

Diap1⁷ is an enhancer of eye phenotype of rpr^GMR.PH

(Hay et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Allele has some 'dominant negative' properties, in that its phenotype is more extreme that of Df(3L)brm11.

(Lisi et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Diap1⁷

th⁷

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close