FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\armS6.Tag:MYC
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General Information
Symbol
Dmel\armS6.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0057832
Feature type
allele
Associated gene
Dmel\arm
Associated Insertion(s)
Carried in Construct
P{arm.S6}
Also Known As
ArmS6
Key Links
Transgenic product class
missense_variant
(Orsulic and Peifer, 1996)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Orsulic and Peifer, 1996)
Mutagen
in vitro construct
(Orsulic and Peifer, 1996)
Progenitor genotype
armS2.Tag:MYC
(Orsulic and Peifer, 1996)
Carried in construct
P{arm.S6}
Cytology
Description

A mutated form of arm, carrying point mutations (amino acid replacements D170A, E171A and D172A) in the first Arm repeat, is expressed under the control of its own promoter. The protein is tagged with a Tag:MYC epitope at residue 784 in the Gly/Pro-rich region close to the C-terminus. arm 3' trailer sequences are also present. The protein produced shows normal levels of binding to α-Cat protein in a coimmunoprecipitation assay, while binding to shg protein is slightly reduced compared to wild-type controls.

(Orsulic and Peifer, 1996)
Allele components
Component
Use(s)
Regulatory region(s)
arm
Encoded product / tool
arm
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos expressing armS6.T:Hsap\MYC in a arm4 background have a "lawn of denticles" cuticle phenotype.

      (Thompson, 2004)

      Embryos exhibit very weak segment polarity defects, adherens junctions are normal.

      (Orsulic and Peifer, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Not rescued by

      arm4, armS6.Tag:MYC is not rescued by Scer\GAL4arm.PS/armUAS.Tag:M(sev)

      (Thompson, 2004)
      Rescues

      armS6.Tag:MYC rescues arm3

      (Orsulic and Peifer, 1996)
      Comments

      The "lawn of denticles" cuticle phenotype seen in embryos carrying armS6.T:Hsap\MYC in an arm4 background is not rescued by ubiquitous expression of armScer\UAS.T:sev-TM using Scer\GAL4arm.PS. Ubiquitous expression of armS10.Scer\UAS.T:Hsap\MYC using Scer\GAL4arm.PS produces ectopic naked cuticle in embryos carrying armS6.T:Hsap\MYC in an arm4 background.

      (Thompson, 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Used in a coimmunoprecipitation assay to study shg binding and analysed by SDS-PAGE to study protein phosphorylation and stability.

      (Orsulic and Peifer, 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      ArmS6
      (Thompson, 2004)
      armS6.T:Hsap\MYC
      armS6.T:Myc
      armS6.Tag:MYC
      armS6
      (van de Wetering et al., 1997)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)