FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\armS14.Tag:MYC
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General Information
Symbol
Dmel\armS14.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0057837
Feature type
allele
Associated gene
Dmel\arm
Associated Insertion(s)
Carried in Construct
P{arm.S14}
Also Known As
armS14
Key Links
Transgenic product class
inframe_deletion
(Orsulic and Peifer, 1996)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Orsulic and Peifer, 1996)
Mutagen
in vitro construct
(Ahmed et al., 1998, Orsulic and Peifer, 1996)
Progenitor genotype
armS2.Tag:MYC
(Orsulic and Peifer, 1996)
Carried in construct
P{arm.S14}
Cytology
Description

A mutated form of arm, lacking the end of the N-terminal region (amino acids 101-139 are deleted), is expressed under the control of its own promoter. The protein is tagged with a Tag:MYC epitope at residue 784 in the Gly/Pro-rich region close to the C-terminus. arm 3' trailer sequences are also present. The protein produced shows slightly reduced levels of binding to shg protein compared to wild-type controls in a coimmunoprecipitation assay and binding to α-Cat protein is abolished.

(Orsulic and Peifer, 1996)
Allele components
Component
Use(s)
Regulatory region(s)
arm
Encoded product / tool
arm
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos expressing armS14.T:Hsap\MYC in an arm1 mutant background do not show a wg loss of function phenotype in the cuticle. The embryos have defects in the ventral epidermis and the head that resemble a weak to moderate shg mutant phenotype. In particular, there are foci of cell death in and around the optic placodes. The optic placode does form but loses its epithelial structure and fails to invaginate in late embryos.

      (Dumstrei et al., 2002)

      The size of the primary branches of the tracheal system is largely unaffected in embryos carrying armS14.T:Hsap\MYC in an arm4 background, even though segments of the dorsal trunk are disconnected.

      (Beitel and Krasnow, 2000)

      Photoreceptors are not rescued from death in ApcQ8 homozygotes carrying one copy of armS14.T:Hsap\MYC in an arm4/+ background.

      (Ahmed et al., 1998)

      Embryos do not exhibit segment polarity defects.

      (Orsulic and Peifer, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      armS14.Tag:MYC partially rescues arm4

      (Loureiro and Peifer, 1998)

      armS14.Tag:MYC partially rescues arm3

      (Orsulic and Peifer, 1996)
      Comments

      The phenotype seen in RP2 neurons in embryos that are zygotically arm4 but have wild-type maternal arm is rescued by armS14.T:Hsap\MYC.

      (Loureiro and Peifer, 1998)

      Partial rescue of adherens junction defect.

      (Orsulic and Peifer, 1996)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Used in a coimmunoprecipitation assay to study shg binding and analysed by SDS-PAGE to study protein phosphorylation and stability.

      (Orsulic and Peifer, 1996)

      Mutation abolished the ability of arm to bind α-Cat in vivo.

      (Pai et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      S14
      (Ahmed et al., 1998)
      armS14.T:Hsap\MYC
      armS14.T:Myc
      armS14.Tag:MYC
      armS14
      (Dumstrei et al., 2002, Loureiro and Peifer, 1998, Miller and Moon, 1996)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)