FlyBase Allele Report: Dmel\sra[A108]

General Information

Symbol

Dmel\sra^A108

Species

D. melanogaster

Name

FlyBase ID

FBal0059932

Feature type

allele

Associated gene

Dmel\sra

Associated Insertion(s)

P{SP^g.Yp1.hs}sra^A108

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Horner, 2006)

Mutagen

P-element activity

(Czank, 1997.5.14)

Progenitor genotype

Associated Insertion(s)

P{SP^g.Yp1.hs}sra^A108

Cytology

Description

The P{Acp70A^g.Yp1.hs} insertion is within the large intron of sra.

(Horner, 2006)

P{lacW} insertion of sra^A381 is 5kb from the P{Acp70A^g.Yp1.hs} insertion of sra^A108.

(Czank, 1997.5.14)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | female (with Df(3R)sbd45)

(Horner, 2006)

abnormal meiotic cell cycle | female (with sra⁶¹⁹)

(Horner, 2006)

abnormal meiotic cell cycle | female (with sra^A426)

(Prudêncio et al., 2018)

female sterile

(Horner, 2006, Czank et al., 1997)

female sterile (with Df(3R)sbd45)

(Horner, 2006)

female sterile | recessive

(Czank, 1997.5.14)

lethal | female

(Czank, 1997.5.14)

some die during immature adult stage | female

(Czank, 1997.5.14)

viable

(Horner, 2006, Horner et al., 2006)

Phenotype Manifest In

male pronucleus (with Df(3R)sbd45)

(Bonnefoy et al., 2007)

male pronucleus (with sra⁶¹⁹)

(Horner et al., 2006)

male pronucleus | maternal effect (with sra^A426)

(Prudêncio et al., 2018)

meiotic anaphase I (with sra⁶¹⁹)

(Horner, 2006)

meiotic anaphase I (with sra⁶⁸⁷)

(Horner, 2006)

meiotic anaphase I (with sra^A426)

(Horner, 2006)

Detailed Description

Statement

Reference

In fertilized eggs from sra^A108/sra^A426, the paternal genome remains arrested in the shape of the decondensed male pronucleus and there is no progress from the meiotic metaphase arrest.

(Prudêncio et al., 2018)

Female meiosis arrests in anaphase of the first meiotic division in eggs derived from sra^A108/Df(3R)sbd45 females. The male pronucleus is condensed but irregular in shape.

(Bonnefoy et al., 2007)

sra^A108/sra⁶¹⁹ eggs are fertilized by sperm as the sperm nucleus can be observed inside the egg. However, the male pronucleus in fertilized eggs is much smaller than that of fully decondensed wild-type male pronuclei seen prior to pronuclear fusion.

(Horner et al., 2006)

Eggs laid by sra^A108/Df(3R)sbd45 and sra^A108/sra⁶¹⁹ mothers arrest during anaphase of the first meiotic division.

The vitelline membranes of eggs laid by sra^A108/Df(3R)sbd45 and sra^A108/sra⁶¹⁹ mothers are cross-linked.

(Horner, 2006)

In homozygous females sex peptide (SP) does not stimulate the oviposition rate. sra^A108/sra^A381 transheterozygotes exhibit high constitutive oviposition, SP cannot further increase the egg-laying rate.

(Czank et al., 1997)

Mating or Sex-Peptide (SP) application induces an increase of wild type female's oviposition rate and reduces her receptivity. Homozygous sra^A108 females show no increase in their oviposition rate after mating or SP application and receptivity is slightly reduced. No effects on males have been observed. 50% of homozygous females die within four days after eclosion.

(Czank, 1997.5.14)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Bin1^R7-18, sra[+]/sra^A108 has female semi-fertile phenotype

(Horner, 2006)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The male nucleus in fertilised eggs derived from Hira^185b/Hira^185b ; sra^A108/Df(3R)sbd45 females is identical in shape and size to the male nucleus in eggs derived from Hira^185b/Hira^185b females.

(Bonnefoy et al., 2007)

Bin1^R7-18/+, sra^A108/+ females show reduced fertility compared to control siblings.

(Horner, 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sra⁶¹⁹

(Horner, 2006)

Rescued by

sra^A108 is rescued by sra^cHa

(Horner, 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Revertants demonstrate the P{Acp70A^g.Yp1.hs} insertion causes the female sterile phenotype.

(Czank et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sra^A108

(Prudêncio et al., 2018, Bonnefoy et al., 2007, Horner, 2006, Horner et al., 2006)

sraA108

(Czank, 1997.5.14)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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