FlyBase Allele Report: Dmel\sra[A426]

General Information

Symbol

Dmel\sra^A426

Species

D. melanogaster

Name

FlyBase ID

FBal0194825

Feature type

allele

Associated gene

Dmel\sra

Associated Insertion(s)

P{lacW}sra^A426

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Horner, 2006)

Mutagen

Delta2-3 transposase

(Horner, 2006)

Progenitor genotype

Associated Insertion(s)

P{lacW}sra^A426

Cytology

Description

A P{lacW} insertion in the large intron of the sra gene, at the same nucleotide as the P{Acp70A^g.Yp1.hs}sra^A108 insertion.

(Horner, 2006)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle (with Df(3R)sbd45)

(Horner et al., 2006)

abnormal meiotic cell cycle (with sra⁶¹⁹)

(Horner et al., 2006)

abnormal meiotic cell cycle | female (with Df(3R)sbd45)

(Horner, 2006)

abnormal meiotic cell cycle | female (with sra⁶¹⁹)

(Horner, 2006, Horner et al., 2006)

abnormal meiotic cell cycle | female (with sra^A108)

(Prudêncio et al., 2018)

female sterile

(Horner, 2006)

female sterile (with Df(3R)sbd45)

(Horner, 2006)

viable

(Horner, 2006, Horner et al., 2006)

Phenotype Manifest In

male pronucleus | maternal effect (with sra^A108)

(Prudêncio et al., 2018)

meiosis II (with sra⁶¹⁹)

(Horner et al., 2006)

meiotic anaphase I (with Df(3R)sbd45)

(Horner, 2006, Horner et al., 2006)

meiotic anaphase I (with sra⁶¹⁹)

(Horner, 2006, Horner et al., 2006)

meiotic anaphase I (with sra^A108)

(Horner, 2006)

Detailed Description

Statement

Reference

In fertilized eggs from sra^A108/sra^A426, the paternal genome remains arrested in the shape of the decondensed male pronucleus and there is no progress from the meiotic metaphase arrest.

(Prudêncio et al., 2018)

Eggs laid by sra^A426/Df(3R)sbd45 mothers arrested in anaphase I show some abnormal anaphase figures, with chromosomes scattered throughout the spindle.

Eggs laid by sra^A426/sra⁶¹⁹ mothers are usually arrested in anaphase I but a few eggs appear to be in meiosis II. The two spindles observed in such eggs are parallel to one another and they are usually asynchronous, with one in metaphase and the other in anaphase. In a few sra^A426/sra⁶¹⁹ eggs, some pycnotic chromosomes appear to separate from the main spindle and nucleate secondary spindles.

(Horner et al., 2006)

Eggs laid by sra^A426/Df(3R)sbd45 and sra^A426/sra⁶¹⁹ mothers arrest during anaphase of the first meiotic division.

The vitelline membranes of eggs laid by sra^A426/Df(3R)sbd45 and sra^A426/sra⁶¹⁹ mothers are cross-linked.

(Horner, 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Bin1^R7-18, sra[+]/sra^A426 has female semi-fertile phenotype

(Horner, 2006)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Bin1^R7-18/+, sra^A426/+ females show reduced fertility compared to control siblings.

(Horner, 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sra⁶¹⁹

(Horner, 2006)

Rescued by

sra^A426 is rescued by sra^cHa

(Horner, 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Revertants demonstrate the P{lacW} insertion causes the female sterile phenotype.

(Horner, 2006)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sra^A426

(Prudêncio et al., 2018, Horner, 2006, Horner et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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