FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rhea2
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General Information
Symbol
Dmel\rhea2
Species
D. melanogaster
Name
FlyBase ID
FBal0062488
Feature type
allele
Associated gene
Dmel\rhea
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    A frameshift occurs after codon 1279; the resulting reading frame terminates after specifying 31 out of frame amino acids.

    (Brown et al., 2002)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    3L:8,566,389..8,566,389 [+]
    Comment:

    Approximate location of small deletion after residue 1279 that leads to a frameshift and early translation termination. The resulting reading frame terminates after specifying 31 out of frame amino acids.

    (Brown et al., 2002)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Adult-generated rhea2 homozygous mutant intestinal stem cell clones have reduced maintenance 7 days and 14 days after clone induction compared to control clones; remaining clones contain fewer cells by day 14.

        (Lin et al., 2013)

        rhea2 dorsal branch terminal cell clones in third instar larvae show a loss of branches and increase in lumen number.

        (Levi et al., 2006)

        Homozygous follicle cell clones that are not situated at the posterior of the egg chamber cause mislocalisation of the oocyte in 50% of egg chambers, while homozygous follicle cell clones at the posterior of the egg chamber do not cause oocyte mispositioning. In egg chambers where there is mislocalisation of the oocyte, the oocyte is in contact with the mutant follicle cell clone in 95% of cases.

        (Becam et al., 2005)

        Embryos maternally and zygotically homozygous for rhea2 exhibit a failure of germ-band retraction and a more severe muscle detachment phenotype than embryos zygotically but not maternally homozygous. In rhea2 mutant embryos the gastric caecae fail to split from two initial evaginations into four slender tubes, the midgut does not elongate and the proventriculus does not form properly (n>30).

        (Brown et al., 2002)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        rhea[+]/rhea2 is an enhancer of visible | recessive phenotype of mys8

        (Prout et al., 1997)

        rhea[+]/rhea2 is an enhancer of visible | recessive phenotype of mysb9

        (Prout et al., 1997)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        rhea[+]/rhea2 is an enhancer of wing phenotype of mys8

        (Prout et al., 1997)

        rhea[+]/rhea2 is an enhancer of wing phenotype of mysb9

        (Prout et al., 1997)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Shows a strong genetic interaction with mysb9; the frequency of wing blisters and the penetrance of the wings held-out phenotype in mysb9 single hemizygotes is increased from 1-2% to 50-60%, and from 60-80% to 90% respectively, if they are also heterozygous for rhea2.

        (Prout et al., 1997)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        rhea2
        (Loer et al., 2008, Levi et al., 2006, Levi et al., 2006, Becam et al., 2005)
        talin2
        (Lin et al., 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (7)