FlyBase Allele Report: Dmel\Sumo[k01211]

General Information

Symbol

Dmel\Sumo^k01211

Species

D. melanogaster

Name

FlyBase ID

FBal0064721

Feature type

allele

Associated gene

Dmel\Sumo

Associated Insertion(s)

P{lacW}Sumo^k01211

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}Sumo^k01211

Cytology

Description

P{lacW} insertion about 10bp upstream of the first exon.

(Schnorr et al., 2001)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile | germline clone

(Nie et al., 2009)

lethal (with Sumo⁰⁴⁴⁹³)

(Schnorr et al., 2001)

lethal | recessive

(BDGP Project Members, 1994-1999)

lethal - all die during embryonic stage | germline clone

(Nie et al., 2009)

some die during embryonic stage | germline clone

(Nie et al., 2009)

Phenotype Manifest In

dorsal appendage (with Sumo⁰⁴⁴⁹³)

(Schnorr et al., 2001)

egg (with Sumo⁰⁴⁴⁹³)

(Schnorr et al., 2001)

egg chamber (with Sumo⁰⁴⁴⁹³)

(Schnorr et al., 2001)

egg chorion | germline clone

(Nie et al., 2009)

embryonic/larval crystal cell

(Milchanowski et al., 2004)

Detailed Description

Statement

Reference

smt3^k01211 germ-line clone embryo-producing females lay relatively few mature eggs. None of these hatch and all unhatched embryos die prior to cuticle formation.

Approximately 30% of smt3^k01211 GLC eggs exhibit defective egg shells.

(Nie et al., 2009)

The average number of crystal cells per embryo is reduced in homozygous stage 13-14 embryos compared to wild type.

(Milchanowski et al., 2004)

0.76% of smt3⁰⁴⁴⁹³/smt3^k01211 animals survive as adult escapers. These females produce few late-stage egg chambers and these rare eggs have poorly developed dorsal appendages.

(Schnorr et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Sumo^k01211/smt3[+] is an enhancer of dorsal appendage phenotype of Ras85D^ix12a

(Schnorr et al., 2001)

Suppressor of

Statement

Reference

Sumo^k01211 is a suppressor of egg chorion phenotype of Scer\GAL4^CU1, btl::Egfr^λ.UAS

(Schnorr et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Moderate dominant enhancer of the Ras85D^ix12a eggshell phenotype; 31-40% of dorsal appendages are wild type.

(Schnorr et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Sumo^EMS

(Nie et al., 2009)

Sumo⁰⁴⁴⁹³

(Nie et al., 2009)

Sumo⁰⁴⁴⁹³

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

102197

y¹ w^67c23 ; P{lacW}Sumo^k01211 / CyO

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Embryos derived from smt3^k01211 and smt3⁰⁴⁴⁹³ germ-line clones (GLC) show an overlapping spectra of defects, with the average severity of defects being greater in smt3^k01211 GLC embryos than smt3⁰⁴⁴⁹³ GLC embryos.

(Nie et al., 2009)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Sumo^k01211

l(2)04493^k01211

(BDGP Project Members, 1994-1999)

l(2)k01211

(Schnorr and Moore, 2006, Schnorr et al., 2001, Schnorr et al., 2001)

smt3^K01211

(Milchanowski et al., 2004)

smt3^k01211

sumo^k01211

(Nie et al., 2009, Nie et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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