FlyBase Allele Report: Dmel\pbl[S054203a]

General Information

Symbol

Dmel\pbl^S054203a

Species

D. melanogaster

Name

FlyBase ID

FBal0082373

Feature type

allele

Associated gene

Dmel\pbl

Associated Insertion(s)

P{lacW}pbl^S054203a

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Salzberg et al., 1997)

Mutagen

Delta2-3 transposase

(Deak et al., 1997)

P-element activity

(Prokopenko et al., 1999, Salzberg et al., 1997)

Progenitor genotype

Associated Insertion(s)

P{lacW}pbl^S054203a

Cytology

Description

P{lacW} insertion 149bp upstream of the AUG start codon.

(Prokopenko et al., 1999)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:7,911,607..7,911,607 [-]

(Prokopenko et al., 2000, Prokopenko et al., 1999, Deak et al., 1997, Salzberg et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of pupal stage | recessive

(Deak et al., 1997, Salzberg et al., 1997)

some die during pupal stage | recessive

(Deak et al., 1997, Salzberg et al., 1997)

Phenotype Manifest In

presumptive embryonic/larval peripheral nervous system

(Salzberg et al., 1997)

Detailed Description

Statement

Reference

10% of embryos exhibit mild fasciculation defects.

(Salzberg et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

pbl^EP3415

(Prokopenko et al., 2000)

pbl⁰⁹⁶⁴⁵

(Prokopenko et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: l(3)S054203b^S054203b.

(Deak et al., 1997)

Comments

Excision of the P{lacW} is accompanied by a reversion to wild-type.

(Prokopenko et al., 1999)

Δ2-3 induced reversion demonstrates the insertion is responsible for the lethal phenotype.

(Salzberg et al., 1997)

External Crossreferences and Linkouts ( 2 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

0542/03

(Deak et al., 1997)

542/3

(Salzberg et al., 1997)

l(3)S054203

(Prokopenko et al., 2000)

pbl^S054203

pbl^S054203a

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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