FlyBase Allele Report: Dmel\sina[GMR.PN]

General Information

Symbol

Dmel\sina^GMR.PN

Species

D. melanogaster

Name

glass multimer reporter construct of Neufeld

FlyBase ID

FBal0086338

Feature type

allele

Associated gene

Dmel\sina

Associated Insertion(s)

Carried in Construct

P{GMR-sina.N}

Also Known As

GMR-sina

Key Links

Transgenic product class

wild_type

(Neufeld et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Neufeld et al., 1998)

Mutagen

in vitro construct

(Neufeld et al., 1998)

Progenitor genotype

Carried in construct

P{GMR-sina.N}

Cytology

Description

GMR regulatory sequences drive expression of the sina coding region.

(Neufeld et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

sina

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Tang et al., 2001, Neufeld et al., 1998)

Phenotype Manifest In

cone cell

(Neufeld et al., 1998)

eye

(Tang et al., 2001, Neufeld et al., 1998)

eye photoreceptor cell

(Neufeld et al., 1998)

ommatidium

(Tang et al., 2001, Neufeld et al., 1998)

pigment cell

(Neufeld et al., 1998)

Detailed Description

Statement

Reference

Flies carrying sina^GMR.PN have a rough eye phenotype.

(Tang et al., 2001)

Flies carrying sina^GMR.PN have eye abnormalities ranging from a slight roughening of the ommatidial lattice to a gross disruption of eye morphology. Strong phenotypes include eyes which are noticeably smaller and less pigmented than wild-type, with a fusion of ommatidial surfaces resulting in a glazed appearance. The underlying retinal cells are disrupted in these eyes, with a severe disruption of patterning, although all cell types (pigment cells, cone cells, photoreceptor cells and bristles) are present in these eyes. Weaker phenotypes include defective ommatidial rotation, lattice disorganisation and occasional missing photoreceptors. Signs of ommatidial disorganisation are visible in pupae 40 hours after pupation. Patterning of the cone cells appears normal in third instar larvae, but is clearly disorganised by 40 hours after pupation.

(Neufeld et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

sina^GMR.PN has visible phenotype, enhanceable by CE2-1^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, enhanceable by CE3-1^unspecified

(Sullivan and Rubin, 2002)

NOT Enhanced by

Statement

Reference

sina^GMR.PN has visible phenotype, non-enhanceable by CE2-2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-enhanceable by CE2-3^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-enhanceable by CE3-2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-enhanceable by CE3-3^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-enhanceable by CS3-1^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-enhanceable by CS3-2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-enhanceable by CS3-4^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-enhanceable by CanB2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-enhanceable by sty^unspecified

(Sullivan and Rubin, 2002)

Suppressed by

Statement

Reference

sina^GMR.PN has visible phenotype, suppressible by lilli^XS407

(Tang et al., 2001)

sina^GMR.PN has visible phenotype, suppressible by lilli^s35

(Tang et al., 2001)

sina^GMR.PN has visible phenotype, suppressible by lilli^XS575

(Tang et al., 2001)

sina^GMR.PN has visible phenotype, suppressible by gl^ES5

(Neufeld et al., 1998)

sina^GMR.PN has visible phenotype, suppressible by E(sina)6^unspecified

(Neufeld et al., 1998)

NOT suppressed by

Statement

Reference

sina^GMR.PN has visible phenotype, non-suppressible by sty^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-suppressible by CanB2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-suppressible by CE2-2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-suppressible by CE2-3^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-suppressible by CE3-2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-suppressible by CE3-3^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-suppressible by CS3-1^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-suppressible by CS3-2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has visible phenotype, non-suppressible by CS3-4^unspecified

(Sullivan and Rubin, 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

sina^GMR.PN has eye phenotype, enhanceable by CE2-1^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, enhanceable by CE3-1^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has phenotype, enhanceable by Hsp83^unspecified

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, enhanceable by ES1-1^unspecified

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, enhanceable by bur^e10

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, enhanceable by Sin3A^unspecified

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, enhanceable by Sin3A^e64

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, enhanceable by S^unspecified

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, enhanceable by S^e220

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, enhanceable by ES3-1^e139

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, enhanceable by ES1-1^e341

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, enhanceable by ES1-1^e401

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, enhanceable by ES2-1^unspecified

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, enhanceable by ES2-1^e1

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, enhanceable by bur^unspecified

(Neufeld et al., 1998)

NOT Enhanced by

Statement

Reference

sina^GMR.PN has eye phenotype, non-enhanceable by CE2-2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-enhanceable by CE2-3^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-enhanceable by CE3-2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-enhanceable by CE3-3^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-enhanceable by CS3-1^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-enhanceable by CS3-2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-enhanceable by CS3-4^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-enhanceable by CanB2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-enhanceable by sty^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has phenotype, non-enhanceable by Ras85D^e1B

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, non-enhanceable by Sos^e4G

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, non-enhanceable by RasGAP1^A13P

(Neufeld et al., 1998)

Suppressed by

Statement

Reference

sina^GMR.PN has ommatidium phenotype, suppressible by lilli^XS407

(Tang et al., 2001)

sina^GMR.PN has ommatidium phenotype, suppressible by lilli^XS575

(Tang et al., 2001)

sina^GMR.PN has ommatidium phenotype, suppressible by lilli^s35

(Tang et al., 2001)

sina^GMR.PN has phenotype, suppressible by gl^unspecified

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, suppressible by lilli^unspecified

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, suppressible by lilli^s35

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, suppressible by SS3-1^unspecified

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, suppressible by eff^unspecified

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, suppressible by eff^s81

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, suppressible by Su(Tpl)^unspecified

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, suppressible by Su(Tpl)^s95

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, suppressible by SS3-5^unspecified

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, suppressible by SS3-6^unspecified

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, suppressible by SS3-6^s297

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, suppressible by fry^unspecified

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, suppressible by fry^s308

(Neufeld et al., 1998)

sina^GMR.PN has eye phenotype, suppressible by gl^ES5

(Neufeld et al., 1998)

sina^GMR.PN has eye phenotype, suppressible by E(sina)6^unspecified

(Neufeld et al., 1998)

NOT suppressed by

Statement

Reference

sina^GMR.PN has eye phenotype, non-suppressible by CE2-2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-suppressible by CE2-3^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-suppressible by CE3-2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-suppressible by CE3-3^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-suppressible by CS3-1^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-suppressible by CS3-2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-suppressible by CS3-4^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-suppressible by CanB2^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has eye phenotype, non-suppressible by sty^unspecified

(Sullivan and Rubin, 2002)

sina^GMR.PN has phenotype, non-suppressible by Ras85D^e1B

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, non-suppressible by Sos^e4G

(Neufeld et al., 1998)

sina^GMR.PN has phenotype, non-suppressible by RasGAP1^A13P

(Neufeld et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The phenotype caused by sina^GMR.PN is suppressed by gl^ES5 and E(sina)6^unspecified, enhanced by Hsp83^unspecified, and unaffected by Ras85D^e1B, Sos^e4G or Gap1^A13P.

(Neufeld et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (4)

Bloomington

30715

w^*; Sin3A^e64/CyO, P{GMR-sina.N}2

30716

w^*; lilli^XS407/CyO, P{GMR-sina.N}2

30717

w^*; eff^s81/TM3, P{GMR-sina.N}3, Sb¹

30718

w^*; fry^s308/TM3, P{GMR-sina.N}3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

sina^GMR.PN

sina^gl

(Sullivan and Rubin, 2002)

Name Synonyms

glass multimer reporter construct of Neufeld

(Neufeld et al., 1998)

Secondary FlyBase IDs

References (4)

Report Sections

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