FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hsc70-4L3929
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General Information
Symbol
Dmel\Hsc70-4L3929
Species
D. melanogaster
Name
FlyBase ID
FBal0087006
Feature type
allele
Associated gene
Dmel\Hsc70-4
Associated Insertion(s)
P{lacW}Hsc70-4L3929
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(BDGP Project Members, 1994-1999)
Progenitor genotype
Associated Insertion(s)
P{lacW}Hsc70-4L3929
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  neuronal ceroid lipofuscinosis
      modeled by cathD1
      (Kuronen et al., 2009)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Hsc70-4L3929/Hsc70-4[+] is an enhancer of eye phenotype of cathD1

      (Kuronen et al., 2009)
      NOT Suppressor of
      Statement
      Reference

      Hsc70-4L3929 is a non-suppressor of eye phenotype of CycEJP

      (Brumby et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A Hsc70-4L3929 mutant background enhances by more than 10-fold the level of vacuolar change in cathD1 mutant retina.

      (Kuronen et al., 2009)

      18% of Hsc70-4L3929/Snr1E1 animals have an incomplete L5 wing vein.

      (Marenda et al., 2004)

      The CycEJP rough eye phenotype not suppressed by the addition of Hsc70-4L3929.

      (Brumby et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Hsc70-4L03929
      (Chang et al., 2002)
      Hsc70-4L3929
      l(3)L3929
      (Beaton, 1999.12.12)
      l(3)L3929L3929
      (BDGP Project Members, 1994-1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)