FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Wnt2RJ
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General Information
Symbol
Dmel\Wnt2RJ
Species
D. melanogaster
Name
FlyBase ID
FBal0089481
Feature type
allele
Associated gene
Dmel\Wnt2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

heat sensitive hypomorphic allele - genetic evidence

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

heat sensitive hypomorphic allele - genetic evidence

(Kozopas, 2003.3, Kozopas and Nusse, 2002)

hypomorphic allele - genetic evidence

(Kozopas et al., 1998)
Mutagen
ethyl methanesulfonate
(Kozopas et al., 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: C342Y.

(Kozopas and Nusse, 2002, Kozopas et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:9,503,005..9,503,005 [+]
Nucleotide change:

G9503005A

Amino acid change:

C342Y | Wnt2-PA; C315Y | Wnt2-PB

Reported amino acid change:

C342Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kozopas et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Huntington's disease
      modeled by Hsap\HTTQ93.ex1.UAS
      (Dupont et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At 18oC: Testes and wings are wild type. At 29oC: Testis phenotype: hypomorphic, loss of some pigment cells but little or no muscle loss. Held out wing phenotype: wings held out at 45 to 90 degrees, loss of DFM 52, hypomorphic for misattachment of other DFMs.

      (Kozopas, 2003.3)

      When grown at 29oC the mutants are flightless due to the absence of muscle 54. When flies are raised at 18oC they are able to fly and display no direct flight muscle mutants.

      (Kozopas and Nusse, 2002)

      With variable penetrance, homozygous males have much smaller testes than wild-type. Testis colour: only some regions of the testis sheath produce yellow pigment. Homozygotes have held out wings.

      (Kozopas et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Wnt2[+]/Wnt2RJ is a suppressor | partially of short lived phenotype of Hsap\HTTQ93.ex1.UAS, Scer\GAL4elav.PU

      (Dupont et al., 2012)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Wnt2RJ/+ significantly partially suppresses the decreased lifespan seen in flies with expression of Hsap\HTTQ93.ex1p.Scer\UAS driven by Scer\GAL4elav.PU.

      (Dupont et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Separable from: uncharacterised lethal.

      (Kozopas, 2003.3)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Dwnt2RJ
      (Dupont et al., 2012)
      Wnt2RJ
      Name Synonyms
      Secondary FlyBase IDs
        References (4)