FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\trxJY16
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General Information
Symbol
Dmel\trxJY16
Species
D. melanogaster
Name
FlyBase ID
FBal0096650
Feature type
allele
Associated gene
Dmel\trx
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Breen, 1999)
    Mutagen
    Progenitor genotype
    Caused by aberration
    Ab(3)JY16
    Cytology
    Description

    trxJY16 is associated with a chromosomal break in the region encoding exon 3. The resulting fusion gene can express unaltered TRXI isoform and perhaps a form of TRXII isoform with novel N-terminal residues.

    (Breen, 1999)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    sequence_alteration
    3R:14,276,564..14,276,878 [-]
    Comment:

    Breakpoint lies within the region encoding amino acids 172-276

    (Breen, 1999)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The brains of trxJY16/trxB11 larvae show a severe reduction in BrdU incorporation compared to wild type. Brain squashes are characterised by global chromatin decondensation, resembling 'prophase-like' chromatin.

        (Muyrers-Chen et al., 2004)

        19.9% of heterozygous adults show at least one transformation phenotype. trxJY16 die as small, lethargic third instar larvae. They do not have obvious segmental transformations, but their trachea are convoluted and may be disjointed.

        (Breen, 1999)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially complements

        trx6.1

        (Breen, 1999)

        trx7.1

        (Breen, 1999)

        trxJY25

        (Breen, 1999)

        trxE3

        (Breen, 1999)

        trxD

        (Breen, 1999)

        trx1

        (Breen, 1999)

        trxZ44

        (Breen, 1999)

        trxZ32

        (Breen, 1999)

        trxZ16

        (Breen, 1999)

        trxZ15

        (Breen, 1999)

        trxZ11

        (Breen, 1999)

        trxM14

        (Breen, 1999)

        trxM18

        (Breen, 1999)

        trxM17

        (Breen, 1999)

        trxB11

        (Breen, 1999)

        trxA7

        (Breen, 1999)
        Comments

        Partial complementation between hypomorphs produced phenotypes that were weaker than either of the hemizygous or homozygous phenotypes, either rescuing lethality or producing a weaker homeotic transformation phenotype. Transformations range from an average of 1.86 to 17.50 transformations/fly (males were scored for a possible 29 transformations, females were scored for a possible 26 transformations) in different allelic combinations.

        (Breen, 1999)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        The following alleles form a series of progressively increasing penetrance and expressivity of phenotype when in transheterozygous combination with trx1 : trxM17 > trxZ32 > trxZ16 > trxZ11 > trxM18 = trxJY16 > trxE3.

        (Breen, 1999)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        trxJY16
        (Muyrers-Chen et al., 2004)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)