FlyBase curator comment: Interactions with Dg and/or Dg were detected in a Dg/+ or Dg/+ background which exhibits no obvious changes in muscle morphology. Nonetheless, these interactions have been captured as 'modifier' ('exacerbates') annotations here to best capture the experimental finding and the authors' intention.
The testes of Lis-1k11702/+ ; asunf02815 mutant males are small compared to controls. There is an extreme paucity of sperm bundles and most of the cells are late G2 primary spermatocytes, indicative of a severe G2 block.
Eggs laid by grk6/Lis-1k11702 mothers show defects in the location and morphology of the dorsal appendages. Most dorsal appendages are fused. This is an enhancement of the grk6/+ or Lis-1k11702/+ phenotypes. Eggs laid by Egfrf24/Lis-1k11702 mothers show an enhancement of the dorsal appendage phenotype seen in Egfrf24/+ or Lis-1k11702/+ flies. The slight loss of viability phenotype seen in Lis-1k11702/Lis-13.3.1, Lis-1k11702/Lis-13.1.2, Lis-1k11702/Lis-18.25.3, Lis-1k11702/Lis-111.4.13 or Lis-1k11702/Lis-17.13.1, is enhanced by the addition of Gl1. The adult escapers from these crosses generally do not survive more than a few days. The addition of these Lis-1 transheterozygote combinations enhances the eye phenotype seen in Gl1 flies. In addition scutellar bristles of escapers flies are reduced in size and frequently lost. Most adult escapers lack bristles on the ventral side of the abdomen, and in many animals abdominal tergites are completely absent in one or more segments.
The expression of Lis-1Scer\UAS.cLa is able to rescue the Lis-1k11702/Lis-1G10.14 giant fiber anatomical defects (full rescue when driven by either Scer\GAL4shot-OK307 or Scer\GAL4GMR91H05) and electrophysiological defects (full rescue when driven by Scer\GAL4shot-OK307; partial rescue when driven by Scer\GAL4GMR91H05).