FlyBase Allele Report: Dmel\Diap1[SL]

General Information

Symbol

Dmel\Diap1^SL

Species

D. melanogaster

Name

FlyBase ID

FBal0103508

Feature type

allele

Associated gene

Dmel\Diap1

Associated Insertion(s)

Carried in Construct

Also Known As

th^sl

Key Links

Genomic Maps

JBrowse

Allele class

gain of function allele

hypermorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

gain of function allele

(Lisi et al., 2000)

hypermorphic allele - genetic evidence

(Choi et al., 2006)

loss of function allele

(Lisi et al., 2000)

Mutagen

ethyl methanesulfonate

(Lisi et al., 2000)

Progenitor genotype

Cytology

Description

Amino acid replacement: V85M. V85 falls in the BIR1 domain.

(Lisi et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:16,039,736..16,039,736 [-]

Nucleotide change:

G16039736A

Amino acid change:

Reported amino acid change:

V85M

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. V85 falls in the BIR1 domain.

(Lisi et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Shulman and Feany, 2003)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Lisi et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

As in wild type, th^SL mutant bursCCAP neurons undergo programmed cell death shortly after eclosion.

(Lee et al., 2013)

th^SL mutants exhibit normal levels of cell death in Crz-expressing ventral nerve cord neurons.

(Choi et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Diap1^SL is an enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Diap1^SL is an enhancer of abnormal cell death phenotype of hid^hs.PG

(Lisi et al., 2000)

Diap1^SL is an enhancer of abnormal cell death phenotype of hid^GMR.PG

(Lisi et al., 2000)

Suppressor of

Statement

Reference

Diap1^SL is a suppressor | partially of increased cell death phenotype of Scer\GAL4^GMR.PF, rpr^UAS.cZa

(Wing et al., 2001)

Diap1^SL is a suppressor of lethal phenotype of Scer\GAL4^GMR.PF, rpr^UAS.cZa

(Wing et al., 2001)

Diap1^SL is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PF, rpr^UAS.cZa

(Wing et al., 2001)

Diap1^SL is a suppressor of abnormal cell death phenotype of rpr^hs.PW

(Lisi et al., 2000)

Diap1^SL is a suppressor of abnormal cell death phenotype of grim^GMR.PC

(Lisi et al., 2000)

Diap1^SL is a suppressor of abnormal cell death phenotype of rpr^GMR.PW

(Lisi et al., 2000)

NOT Suppressor of

Statement

Reference

Diap1^SL is a non-suppressor of lethal phenotype of Scer\GAL4^GMR.PF, hid^UAS.cZa

(Wing et al., 2001)

Diap1^SL, Scer\GAL4^GMR.PF is a non-suppressor of lethal phenotype of Scer\GAL4^GMR.PF, grim^UAS.cNa

(Wing et al., 2001)

Other

Statement

Reference

Diap1^SL, rpr^hs.PW has viable phenotype

(Lisi et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

Diap1^SL is an enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Diap1^SL is an enhancer of ommatidium phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Diap1^SL is an enhancer of embryo phenotype of hid^hs.PG

(Lisi et al., 2000)

Diap1^SL is an enhancer of adult phenotype of hid^hs.PG

(Lisi et al., 2000)

Diap1^SL is an enhancer of eye phenotype of hid^GMR.PG

(Lisi et al., 2000)

Suppressor of

Statement

Reference

Diap1^SL is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, rpr^UAS.cZa

(Wing et al., 2001)

Diap1^SL is a suppressor of eye phenotype of rpr^GMR.PW

(Lisi et al., 2000)

Diap1^SL is a suppressor of embryo phenotype of rpr^hs.PW

(Lisi et al., 2000)

Diap1^SL is a suppressor of eye phenotype of grim^GMR.PC

(Lisi et al., 2000)

NOT Suppressor of

Statement

Reference

Diap1^SL is a non-suppressor of phenotype of Hsap\CDKN1A^GMR.PH

(Lisi et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Suppression of rpr^GMR.PW and grim^GMR.PC in the eye is almost complete though enhancement of W^GMR.PG is mild. Increases the viability of rpr^hs.PW flies threefold, but slightly enhances W^hs.PG-induced death.

(Lisi et al., 2000)

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced by th^SL.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

98348

Diap1^SL

Notes on Origin

Discoverer

Comments

Behaves as a gain of function allele with respect to rpr- and grim-induced cell death. Behaves as a weak loss of function with respect to W-induced cell death: in the eye and the embryo W-induced cell death is not inhibited by th^SL, it is enhanced.

(Lisi et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

DIAP1^SL

(Lee et al., 2013)

Diap1^SL

th^SL

(Lee et al., 2013, Choi et al., 2006)

th^sl

(Wing et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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