FlyBase Allele Report: Dmel\Nsf2[103]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Nsf2¹⁰³

General Information

Symbol

Dmel\Nsf2¹⁰³

Species

D. melanogaster

Name

FlyBase ID

FBal0124111

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Golby et al., 2001)

Mutagen

ethyl methanesulfonate

(Golby et al., 2001)

Progenitor genotype

Cytology

Description

334bp deletion in Nsf2 that completely removes a 240bp intron, as well as flanking 5' and 3' exon sequences. This fuses the first two bases of codon 438 to the first base of codon 470, resulting in a frameshift that replaces the final 314 Nsf2 codons by 43 novel codons and then a translation termination signal.

(Golby et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

3R:13,835,532..13,835,864 [-]

Comment:

A 334 nucleotide deletion, including an intron, that fuses the first two bases of codon 438 to the first base of codon 470. The predicted result is a frameshift that leads to a severely truncated protein consisting of the first 438 amino acids of Nsf2 followed by 37 novel amino acids.

(Golby et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | recessive

(Golby et al., 2001)

some die during larval stage | recessive

(Golby et al., 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

Hemizygotes have apparently normal embryogenesis and hatch, but die as larvae at the mid-first instar.

(Golby et al., 2001)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Nsf2¹⁰³ has lethal | recessive | larval stage phenotype, suppressible by comt^hs.PP

(Golby et al., 2001)

NOT suppressed by

Statement

Reference

Nsf2¹⁰³ has lethal | recessive | larval stage phenotype, non-suppressible by Scer\GAL4^how-24B/comt^UAS.cGa

(Golby et al., 2001)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

(Golby et al., 2001)

Fails to complement

(Golby et al., 2001)

(Golby et al., 2001)

(Golby et al., 2001)

(Golby et al., 2001)

(Golby et al., 2001)

(Golby et al., 2001)

Rescued by

Nsf2¹⁰³ is rescued by Nsf2^hs.PG

(Golby et al., 2001)

Nsf2¹⁰³ is rescued by Scer\GAL4^elav-C155/Nsf2^UAS.cGa/Scer\GAL4^how-24B

(Golby et al., 2001)

Partially rescued by

Nsf2¹⁰³ is partially rescued by Nsf2^UAS.cGa/Scer\GAL4^how-24B

(Golby et al., 2001)

Not rescued by

Nsf2¹⁰³ is not rescued by Scer\GAL4^elav-C155/Nsf2^UAS.cGa

(Golby et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Nsf2¹⁰³

dNSF2¹⁰³

(Golby et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections