FlyBase Allele Report: Dmel\morgue[EP1184]

General Information

Symbol

Dmel\morgue^EP1184

Species

D. melanogaster

Name

FlyBase ID

FBal0129220

Feature type

allele

Associated gene

Dmel\morgue

Associated Insertion(s)

P{EP}morgue^EP1184

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Hays et al., 2002, Wing et al., 2002)

Mutagen

P-element activity

(Hays et al., 2002, Wing et al., 2002, Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EP}morgue^EP1184

Cytology

Description

P{EP} insertion 113bp downstream of the CT35501 stop codon, in the 3' untranslated region.

(Hays et al., 2002)

P{EP} insertion in the 3' untranslated region. The P{EP} insert is in the opposite orientation to the direction of morgue transcription.

(Wing et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:4,442,958..4,442,958 [-]

(Kuo et al., 2006, Hays et al., 2002, Wing et al., 2002, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell death | recessive

(Hays et al., 2002)

melanotic mass phenotype

(Hays et al., 2002)

partially lethal - majority die (with Df(2L)dp-h25)

(Wing et al., 2002)

viable

(Hays et al., 2002)

visible (with Df(2L)dp-h25)

(Wing et al., 2002)

Phenotype Manifest In

chaeta (with Df(2L)dp-h25)

(Wing et al., 2002)

leg (with Df(2L)dp-h25)

(Wing et al., 2002)

melanotic mass

(Hays et al., 2002)

pigment cell | increased number (with morgue^EP2367)

(Hays et al., 2002)

Detailed Description

Statement

Reference

Expression of morgue^EP1184 under the control of Scer\GAL4^vg.PM or Scer\GAL4^ptc.PU does not result in any apparent phenotypes.

(Colin et al., 2014)

morgue^EP1184 mutants do not exhibit defects in dendrite pruning or neuronal cell death 18-20 hours after puparium formation.

(Kuo et al., 2006)

Apoptosis in the pigment cell lattice is disrupted in morgue^EP1184/morgue^EP2367 flies, resulting in extra cells in the mature retina. At eclosion, 30% of homozygotes have visible melanotic tumours, compared to 0% of wild-type flies.

(Hays et al., 2002)

morgue^EP1184/Df(2L)dp-h25 surviving adults have short, thin bristles and some have leg truncations.

(Wing et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

morgue^EP1184 is a non-enhancer of visible | adult stage phenotype of Mmus\Bax^UAS.cGa, Scer\GAL4^vg.PM

(Colin et al., 2014)

morgue^EP1184 is a non-enhancer of visible | adult stage phenotype of Debcl^UAS.Tag:HA, Scer\GAL4^ptc.PU

(Colin et al., 2014)

Suppressor of

Statement

Reference

morgue[+]/morgue^EP1184 is a suppressor of increased cell death phenotype of hid^GMR.PG

(Hays et al., 2002)

morgue[+]/morgue^EP1184 is a suppressor of visible phenotype of rpr^GMR.PW

(Hays et al., 2002)

morgue[+]/morgue^EP1184 is a suppressor of increased cell death phenotype of rpr^GMR.PW

(Hays et al., 2002)

morgue[+]/morgue^EP1184 is a suppressor of visible phenotype of grim^GMR.PHb

(Hays et al., 2002)

morgue[+]/morgue^EP1184 is a suppressor of increased cell death phenotype of grim^GMR.PHb

(Hays et al., 2002)

morgue[+]/morgue^EP1184 is a suppressor of visible phenotype of hid^GMR.PG

(Hays et al., 2002)

morgue[+], morgue^EP1184, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, grim::rpr^rg.UAS

(Wing et al., 2002)

NOT Suppressor of

Statement

Reference

morgue^EP1184 is a non-suppressor of visible | adult stage phenotype of Debcl^UAS.Tag:HA, Scer\GAL4^ptc.PU

(Colin et al., 2014)

morgue^EP1184 is a non-suppressor of visible | adult stage phenotype of Mmus\Bax^UAS.cGa, Scer\GAL4^vg.PM

(Colin et al., 2014)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

morgue^EP1184 is a non-enhancer of wing | adult stage phenotype of Mmus\Bax^UAS.cGa, Scer\GAL4^vg.PM

(Colin et al., 2014)

morgue^EP1184 is a non-enhancer of wing | adult stage phenotype of Debcl^UAS.Tag:HA, Scer\GAL4^ptc.PU

(Colin et al., 2014)

Suppressor of

Statement

Reference

morgue[+]/morgue^EP1184 is a suppressor of eye phenotype of hid^GMR.PG

(Hays et al., 2002)

morgue[+]/morgue^EP1184 is a suppressor of ommatidium phenotype of hid^GMR.PG

(Hays et al., 2002)

morgue[+]/morgue^EP1184 is a suppressor of eye phenotype of rpr^GMR.PW

(Hays et al., 2002)

morgue[+]/morgue^EP1184 is a suppressor of ommatidium phenotype of rpr^GMR.PW

(Hays et al., 2002)

morgue[+]/morgue^EP1184 is a suppressor of eye phenotype of grim^GMR.PHb

(Hays et al., 2002)

morgue[+], morgue^EP1184, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, grim::rpr^rg.UAS

(Wing et al., 2002)

NOT Suppressor of

Statement

Reference

morgue^EP1184 is a non-suppressor of wing | adult stage phenotype of Debcl^UAS.Tag:HA, Scer\GAL4^ptc.PU

(Colin et al., 2014)

morgue^EP1184 is a non-suppressor of wing | adult stage phenotype of Mmus\Bax^UAS.cGa, Scer\GAL4^vg.PM

(Colin et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The presence of morgue^EP1184 does not significantly affect the adult wing phenotype of flies expressing Debcl^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ptc.PU.

(Colin et al., 2014)

The eye cell death phenotype caused by expression of grim::rpr^rg.Scer\UAS under the control of Scer\GAL4^GMR.PF is suppressed by heterozygosity for morgue^EP1184.

(Wing et al., 2002)

Xenogenetic Interactions

Statement

Reference

The presence of morgue^EP1184 does not significantly affect the notched wing phenotype observed in flies expressing Mmus\Bax^Scer\UAS.cGa under the control of Scer\GAL4^vg.PM.

(Colin et al., 2014)

Complementation and Rescue Data

Fails to complement

morgue^E290

(Hays et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

16996