FlyBase Allele Report: Dmel\hpo[42-48]

General Information

Symbol

Dmel\hpo^42-48

Species

D. melanogaster

Name

FlyBase ID

FBal0151856

Feature type

allele

Associated gene

Dmel\hpo

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Wu et al., 2003)

Progenitor genotype

Cytology

Description

A 20bp deletion in the hpo ORF, leading to a product lacking most of the C-terminal non-catalytic domain.

(Wu et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Wu et al., 2003)

partially lethal - majority die | pupal stage | somatic clone

(Wu et al., 2003)

Phenotype Manifest In

adult head | somatic clone

(Polesello et al., 2006)

eye disc | larval stage | somatic clone

(Hu et al., 2022)

wing disc | somatic clone

(Qing et al., 2014)

Detailed Description

Statement

Reference

Animals bearing hpo^42-48 clones show an overgrowth phenotype in the head.

(Polesello et al., 2006)

When somatic clones of hpo^42-48 homozygous cells are generated throughout the eye disc using Scer\FLP1^ey.PN with P{neoFRT}42D, only 30% of animals survive the pupal stage and eclose.

(Wu et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

hpo^42-48/hpo[+] is a suppressor | partially of decreased body size | adult stage phenotype of Rassf^X16

(Polesello et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

hpo^42-48 has adult head | somatic clone phenotype, enhanceable by Rassf^X36

(Polesello et al., 2006)

Suppressed by

Statement

Reference

hpo^42-48 has wing disc | somatic clone phenotype, suppressible by Scer\GAL4^Tub.PU/Ncoa6^HMS00664

(Qing et al., 2014)

hpo^42-48 has wing disc | somatic clone phenotype, suppressible by trr^HMS01019/Scer\GAL4^Tub.PU

(Qing et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Ncoa6^HMS00664 under the control of Scer\GAL4^tub.PU suppresses the overgrowth seen in hpo^42-48 mutant wing disc clones.

Expression of trr^HMS01019 under the control of Scer\GAL4^tub.PU suppresses the overgrowth seen in hpo^42-48 mutant wing disc clones.

(Qing et al., 2014)

The head overgrowth phenotype of flies carrying hpo^42-48 clones is enhanced in a Rassf^X36 background.

(Polesello et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

hpo^42-48 is rescued by hpo^+t4.0

(Wu et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

hpo^42-48

(Hu et al., 2022, Qing et al., 2014, Polesello et al., 2006, Polesello et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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