FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RassfX36
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General Information
Symbol
Dmel\RassfX36
Species
D. melanogaster
Name
FlyBase ID
FBal0212718
Feature type
allele
Associated gene
Dmel\Rassf
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Polesello et al., 2006)
Mutagen
P-element activity
(Polesello et al., 2006)
Progenitor genotype
P{EP}RassfGE23517
(Polesello et al., 2006)
Cytology
Description

Excision of the P{EP} element, resulting in a deletion of 620bp of the Rassf gene, starting from the original insertion site.

(Polesello et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      RassfX36 flies are less resistant to γ-irradiation than controls.

      (Polesello et al., 2006)

      The body weight of RassfX16/RassfX36 flies is around 15% lower than wild-type flies.

      (Polesello et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      RassfX36 is an enhancer of adult head | somatic clone phenotype of hpo42-48

      (Polesello et al., 2006)

      RassfX36 is an enhancer of adult head | somatic clone phenotype of hpoKC203

      (Polesello et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Larval eye discs containing Ras85DΔC40B, RassfX36 double mutant clones show a partial rescue of the increased cell death phenotype observed in discs with Ras85DΔC40B single mutant clones.

      (Polesello et al., 2006)

      The reduced body mass phenotype of RassfX36 flies is partially suppressed by one copy of hpo42-48.

      The head overgrowth phenotype of flies carrying either hpo42-48 or hpoKC203 clones is enhanced in a RassfX36 background. In contrast, the overgrowth phenotype of flies carrying hpo42-47 clones is not significantly enhanced by RassfX36.

      Double-mutant Ras85DΔC40B, RassfX36 clones in the eye show a rescue of the growth defect seen in single mutant Ras85DΔC40B clones.

      (Polesello et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      RASSFX36
      (Neal et al., 2022)
      RassfX36
      dRASSFX36
      (Polesello et al., 2006, Polesello et al., 2006)
      rassf36
      (Zheng et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)