FlyBase Allele Report: Dmel\hpo[42-20]

General Information

Symbol

Dmel\hpo^42-20

Species

D. melanogaster

Name

FlyBase ID

FBal0151858

Feature type

allele

Associated gene

Dmel\hpo

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Wu et al., 2003)

Mutagen

X ray

(Wu et al., 2003)

Progenitor genotype

Cytology

Description

A 251bp deletion in hpo. The resulting predicted gene product lacks the C-terminal 90 amino acids.

(Wu et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Wu et al., 2003)

Phenotype Manifest In

adult external head | somatic clone

(Wu et al., 2003)

eye | somatic clone

(Wu et al., 2003)

ommatidium | somatic clone

(Wu et al., 2003)

Detailed Description

Statement

Reference

When somatic clones of hpo^42-20 homozygous cells are generated throughout the eye disc using Scer\FLP1^ey.PN with P{neoFRT}42D, 90% of the animals survive the pupal stage and eclose. The resulting flies have less overgrowth and folding of eyes and head cuticle, and greater numbers of well defined ommatidial facets than if hpo^42-47 is used.

(Wu et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

hpo^+t4.0, hpo^42-20 has partially lethal - majority die phenotype, enhanceable by wts^x1/wts[+]

(Wu et al., 2003)

hpo^+t4.0, hpo^42-20 has partially lethal - majority die phenotype, enhanceable by sav[+]/sav³

(Wu et al., 2003)

hpo^+t4.0, hpo^42-20 has partially lethal - majority die phenotype, enhanceable by sav[+]/sav⁴

(Wu et al., 2003)

NOT Enhanced by

Statement

Reference

hpo^+t4.0, hpo^42-20 has partially lethal - majority die phenotype, non-enhanceable by Tsc1²⁹/Tsc1[+]

(Wu et al., 2003)

hpo^+t4.0, hpo^42-20 has partially lethal - majority die phenotype, non-enhanceable by gig[+]/gig¹⁹²

(Wu et al., 2003)

NOT suppressed by

Statement

Reference

hpo^+t4.0, hpo^42-20 has partially lethal - majority die phenotype, non-suppressible by Tsc1²⁹/Tsc1[+]

(Wu et al., 2003)

hpo^+t4.0, hpo^42-20 has partially lethal - majority die phenotype, non-suppressible by gig[+]/gig¹⁹²

(Wu et al., 2003)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The semi-lethal phenotype of hpo^42-20/hpo^42-20 P{hpo.t4.0}star animals is enhanced to complete lethality by heterozygosity for wts^x1, sav³ or sav⁴, but not Tsc1²⁹ or gig¹⁹².

(Wu et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

hpo^42-20 is rescued by hpo^+t4.0

(Wu et al., 2003)

Comments

Nine out of ten independent transgenic hpo^+t4.0 lines tested fully rescue hpo^42-20. The remaining insertion line (P{hpo.t4.0}star) partially only partially rescues: 34% of animals eclose, and these display a range of phenotypes such as held-out wings and mild overgrowth.

(Wu et al., 2003)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

hpo^42-20

(Baumgartner et al., 2010, Baumgartner et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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