FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Egfr::kek1KEΔCG.UAS.GFP
Open Close
General Information
Symbol
Dmel\Egfr::kek1KEΔCG.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0156490
Feature type
allele
Associated gene
Egfr::kek1
Associated Insertion(s)
Carried in Construct
P{UAS-kek1::Egfr.KEΔCG}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Alvarado et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-kek1::Egfr.KEΔCG}
Cytology
Description

UAS regulatory sequences drive expression of a chimeric construct consisting of the extracellular and transmembrane domains of kek1 fused to a portion of the cytoplasmic domain of Egfr (which includes the kinase domain but lacks the C-tail). The chimeric protein is tagged at the C-terminal end with GFP.

(Alvarado et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Egfr::kek1
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Egfr::kek1KEΔCG.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4CY2 results in eggs with dorsalised chorions. Expression of Egfr::kek1KEΔCG.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4GMR.PF results in a rough eye phenotype.

      (Alvarado et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      Egfr::kek1KEΔCG.UAS.GFP, Scer\GAL4CY2 has egg chorion phenotype, non-suppressible by Egfr[+]/Egfrt1

      (Alvarado et al., 2004)

      Egfr::kek1KEΔCG.UAS.GFP, Scer\GAL4CY2 has egg chorion phenotype, non-suppressible by grk3/grk[+]

      (Alvarado et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The dorsalised chorion phenotype caused by expression of Egfr::kek1KEΔCG.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4CY2 is completely suppressed by coexpression of kek1Scer\UAS.cGa or EgfrDN.Scer\UAS.cBa and is partially suppressed if the flies are also heterozygous for one of Df(2R)Egfr3 or Egfrf8. The dorsalised chorion phenotype caused by expression of Egfr::kek1KEΔCG.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4CY2 is not suppressed if the flies are also heterozygous for one of Egfrt1 or grk3.

      (Alvarado et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Egfr::kek1KEΔCG.Scer\UAS.T:Avic\GFP
      Egfr::kek1KEΔCG.UAS.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)