FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\chrb180
Open Close
General Information
Symbol
Dmel\chrb180
Species
D. melanogaster
Name
FlyBase ID
FBal0175737
Feature type
allele
Associated gene
Dmel\chrb
Associated Insertion(s)
P{EP}chrb-180
P{EP}EP1035
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Reiling and Hafen, 2004)
Progenitor genotype
chrbEP1035
(Reiling and Hafen, 2004)
Associated Insertion(s)
P{EP}chrb-180
P{EP}EP1035
Cytology
Description

Retains the original P{EP}chrbEP1035 insertion and also contains a new P{EP} insertion (in the opposite orientation) in the 5' untranslated region, approximately 450bp upstream of the chrb open reading frame.

(Reiling and Hafen, 2004)
Allele components
Component
Use(s)
Inserted element
P{EP}
P{EP}
Regulatory region(s)
UAS
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant flies have the same weight as control flies. Clones in the adult eye show no increase in cell size in the mutant ommatidia. Under starvation conditions, homozygous flies live significantly shorter than control flies.

      (Reiling and Hafen, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      scylEP9.85 chrb180/Df(3L)vin4 double mutant flies have increased body weight compared to control flies. scyl31 chrb180/Df(3L)vin4 double mutant flies have increased body weight compared to control flies. scyl113 chrb180/Df(3L)vin4 double mutant flies have increased body weight compared to control flies. Cells in scyl113 chrb180 double mutant clones in the eye are slightly enlarged compared to wild type. Cells in scylEP9.85 chrb180 double mutant clones in the eye are slightly enlarged compared to wild type. scyl113 chrb180, scyl31 chrb180 and scylEP9.85 chrb180 double homozygotes are sensitive to hypoxia; double homozygotes show reduced survival to adulthood under hypoxic conditions compared to normoxic conditions. The large eye phenotype seen in animals in which the head is homozygous for gig192 (induced using the eyFLP system) is not further enhanced if the heads are also homozygous for both scylEP9.85 and chrb180.

      (Reiling and Hafen, 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      char180
      (Reiling and Hafen, 2004)
      chrb180
      Name Synonyms
      Secondary FlyBase IDs
        References (1)