FlyBase Allele Report: Dmel\Sirt2[5B-2-35]

General Information

Symbol

Dmel\Sirt2^5B-2-35

Species

D. melanogaster

Name

FlyBase ID

FBal0181533

Feature type

allele

Associated gene

Dmel\Sirt2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Xie and Golic, 2005.6.1)

Mutagen

recombination

(Xie and Golic, 2005.6.1)

I-CreI

(Xie and Golic, 2005.6.1)

ends-in gene targeting

(Xie and Golic, 2005.6.1)

Progenitor genotype

Cytology

Description

Deletion of the Sirt2 coding region.

(Xie and Golic, 2005.6.1)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Luthi-Carter et al., 2010)

ameliorates neurodegenerative disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Pallos et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior

(Dobbelaere et al., 2020)

abnormal touch response | third instar larval stage

(Dobbelaere et al., 2020)

decreased fecundity | male

(Dobbelaere et al., 2020)

male semi-sterile

(Dobbelaere et al., 2020)

viable

(Dobbelaere et al., 2020)

Phenotype Manifest In

centriole

(Dobbelaere et al., 2020)

spermatid axoneme | P-stage

(Dobbelaere et al., 2020)

spermatozoon

(Dobbelaere et al., 2020)

wing disc | third instar larval stage

(Dobbelaere et al., 2020)

Detailed Description

Statement

Reference

Sirt2^5B-2-35 males exhibit a reduction in sperm motility and defects in pupal spermatid axoneme.

Sirt2^5B-2-35 adults exhibit a reduction in their climbing ability.

Sirt2^5B-2-35 wing disc centrioles are shorter and spermatocyte centrioles display extensions positive for Ana1.

(Dobbelaere et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Sirt2^5B-2-35 has male semi-sterile phenotype, enhanceable by HDAC6^KO

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has decreased fecundity | male phenotype, enhanceable by HDAC6^KO

(Dobbelaere et al., 2020)

NOT Enhanced by

Statement

Reference

Sirt2^5B-2-35 has male semi-sterile phenotype, non-enhanceable by Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has abnormal touch response | third instar larval stage phenotype, non-enhanceable by Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has abnormal locomotor behavior phenotype, non-enhanceable by Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has decreased fecundity | male phenotype, non-enhanceable by Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has abnormal touch response | third instar larval stage phenotype, non-enhanceable by HDAC6^KO

(Dobbelaere et al., 2020)

Suppressed by

Statement

Reference

Sirt2^5B-2-35 has abnormal locomotor behavior phenotype, suppressible by HDAC6^KO

(Dobbelaere et al., 2020)

NOT suppressed by

Statement

Reference

Sirt2^5B-2-35 has abnormal touch response | third instar larval stage phenotype, non-suppressible by Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has abnormal locomotor behavior phenotype, non-suppressible by Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has decreased fecundity | male phenotype, non-suppressible by Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has abnormal touch response | third instar larval stage phenotype, non-suppressible by HDAC6^KO

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has male semi-sterile phenotype, non-suppressible by Cep97^Δ

(Dobbelaere et al., 2020)

NOT Enhancer of

Statement

Reference

Sirt2^5B-2-35 is a non-enhancer of decreased fecundity | male phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 is a non-enhancer of male semi-sterile phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 is a non-enhancer of abnormal touch response | third instar larval stage phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 is a non-enhancer of abnormal locomotor behavior phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Suppressor of

Statement

Reference

Sirt2^5B-2-35/Sirt2[+] is a suppressor of abnormal neuroanatomy phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

NOT Suppressor of

Statement

Reference

Sirt2^5B-2-35 is a non-suppressor of male semi-sterile phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 is a non-suppressor of abnormal touch response | third instar larval stage phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 is a non-suppressor of abnormal locomotor behavior phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 is a non-suppressor of decreased fecundity | male phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35/Sirt2[+] is a non-suppressor of increased mortality phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

Other

Statement

Reference

HDAC6^KO, Sirt2^5B-2-35 has viable phenotype

(Dobbelaere et al., 2020)

Cep97^Δ, Sirt2^5B-2-35 has viable phenotype

(Dobbelaere et al., 2020)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Sirt2^5B-2-35 has spermatozoon phenotype, non-enhanceable by Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has spermatid axoneme | P-stage phenotype, non-enhanceable by Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has wing disc | third instar larval stage phenotype, non-enhanceable by HDAC6^KO

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has centriole phenotype, non-enhanceable by HDAC6^KO

(Dobbelaere et al., 2020)

NOT suppressed by

Statement

Reference

Sirt2^5B-2-35 has spermatozoon phenotype, non-suppressible by Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has spermatid axoneme | P-stage phenotype, non-suppressible by Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has wing disc | third instar larval stage phenotype, non-suppressible by HDAC6^KO

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 has centriole phenotype, non-suppressible by HDAC6^KO

(Dobbelaere et al., 2020)

NOT Enhancer of

Statement

Reference

Sirt2^5B-2-35 is a non-enhancer of wing disc | third instar larval stage phenotype of HDAC6^KO

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 is a non-enhancer of centriole phenotype of HDAC6^KO

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 is a non-enhancer of spermatozoon phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 is a non-enhancer of spermatid axoneme | P-stage phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 is a non-enhancer of wing disc | third instar larval stage phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Suppressor of

Statement

Reference

Sirt2^5B-2-35 is a suppressor of primary spermatocyte | P-stage phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35/Sirt2^5B-2-35 is a suppressor | partially of rhabdomere of eye photoreceptor cell phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Luthi-Carter et al., 2010)

Sirt2^5B-2-35/Sirt2[+] is a suppressor | partially of rhabdomere of eye photoreceptor cell phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Luthi-Carter et al., 2010)

Sirt2^5B-2-35/Sirt2[+] is a suppressor of photoreceptor neuron phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Pallos et al., 2008)

NOT Suppressor of

Statement

Reference

Sirt2^5B-2-35 is a non-suppressor of wing disc | third instar larval stage phenotype of HDAC6^KO

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 is a non-suppressor of centriole phenotype of HDAC6^KO

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 is a non-suppressor of spermatozoon phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 is a non-suppressor of spermatid axoneme | P-stage phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Sirt2^5B-2-35 is a non-suppressor of wing disc | third instar larval stage phenotype of Cep97^Δ

(Dobbelaere et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The rhabdomere loss observed upon expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav.PU is partially rescued by Sirt2^5B-2-35 homozygosity or Heterozygosity.

(Luthi-Carter et al., 2010)

A reduction in the level of Sirt2, through a Sirt2^5B-2-35 heterozygous background, leads to greater survival of photoreceptor neurons in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} under the control of Scer\GAL4^elav-C155, although this background does not suppress lethality.

(Pallos et al., 2008)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8839

w¹¹¹⁸; Sirt2^5B-2-35

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Sirt2^5B-2-35

(Poe et al., 2020, Yan et al., 2018, Luthi-Carter et al., 2010)

Sirt2^KO

(Yan et al., 2018)

Sirt2^Δ

(Dobbelaere et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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