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General Information
Symbol
Dmel\egg1473
Species
D. melanogaster
Name
FlyBase ID
FBal0190397
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

856bp in-frame internal deletion which removes the entire SET domain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

egg1473/Df(2R)Dll-MP transheterozygotes are semi-lethal, display a low male:female ratio, and the few males die within 2-3 days; egg1473/Df(2R)ED4065 transheterozygotes are near lethal and no adult males eclose. egg1473/Df(2R)Dll-MP and egg1473/Df(2R)ED4065 transheterozygous adults exhibit shaky, uncoordinated movements and held-out wings that are incompletely expanded, as compared to controls; the locomotor and wing phenotypes of egg1473/Df(2R)Dll-MP transheterozygotes are more pronounced in males than in females. egg1473 homozygotes exhibit increased mortality during the pupal and pharate adult stages, but not during the larval stage, as compared to controls.

egg1473/Df(2R)Dll-MP transheterozygosity results in early oogenesis defects in the germarium, including a strong increase in the number of putative germ stem cells (exhibiting spectrosomes), a decreased number of germline cysts and an associated decrease in the number of egg chambers budding from the germarium, as compared to controls.

The generation of egg1473-homozygous germline clone cysts, either in larvae or adults, leads to an apparently normal progression of oogenesis until arrest and apoptosis of stage 5 egg chambers, as compared to controls. Although initially present in the germarium at similar frequency as controls, clonal egg1473 germline stem cells become progressively lost after clone induction; egg1473 follicle stem cell clones are initially less frequent in the ovary as compared to control clones, and also become progressively lost after clone induction.

57.6% of homozygous females and 2.1% of homozygous males survive to adulthood.

68.6% of egg1473/Df(2R)Dll-MP females and 13.3% of egg1473/Df(2R)Dll-MP males survive to adulthood.

Homozygous egg1473 mutant germ-line clones do not produce any eggs and the mutant egg chambers eventually degenerate.

egg1473 does not dominantly suppress variegation of the w gene caused by In(1)wm4 or P{RS5}5-HA-1992.

egg1473 dominantly suppresses variegation of the w gene caused by P{RS5}5-HA-1902, T(2;3)V21-P{lacW}92E.x3 and P{RS3}panCB-5204-3.

egg1473/Df(2R)Dll-MP females have tiny ovaries consisting of germaria that do not bud off normal egg chambers. Many of these germaria lack recognisable regions and instead appear teardrop-shaped and are full of replicating germ cells and germline cysts that form no apparent egg chambers. Follicle and prefollicle cells are reduced in number and fail to completely encapsulate germline cysts. In the rare partially encapsulated cysts that do exist, germ cells show at least partial differentiation as nurse cells and oocytes.

egg1473/Df(2R)Dll-MP ovaries show an increased level of apoptosis compared to control ovaries. Apoptosis is seen in both somatic and germ cells within the mutant ovaries, but it is predominantly seen in the somatic cells. The majority of apoptotic somatic cells are found in the posterior region of the germaria, with the cells being found between incompletely budded egg chambers and anterior germ cells.

The frequency of germ cell mitoses in egg1473/Df(2R)Dll-MP ovaries is not significantly different from wild type, but the frequency of mitosis in somatic cells of the mutant germaria is significantly reduced compared to wild type.

egg chamber egg1473/Df(2R)Dll-MP ovaries contain germaria but no budded egg chambers.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

egg1473 has egg chamber | germline clone phenotype, non-enhanceable by wded06198

NOT suppressed by
Statement
Reference

egg1473 has egg chamber | germline clone phenotype, non-suppressible by wded06198

Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

Polytene chromosomes in egg1473 ; Su(var)3-96 double mutant larval salivary glands are less condensed than normal and the chromocenter is ill defined.

Germ-line clones doubly mutant for wded06198 and egg1473 show the same phenotype as either single mutant.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (11)