FlyBase Allele Report: Dmel\lqfR[Δ117]

General Information

Symbol

Dmel\lqfR^Δ117

Species

D. melanogaster

Name

FlyBase ID

FBal0191038

Feature type

allele

Associated gene

Dmel\lqfR

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Lee et al., 2009)

Mutagen

Delta2-3 transposase

(Lee et al., 2009)

Progenitor genotype

P{PZ}lqfR⁰³⁶⁸⁵

(Lee et al., 2009)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion of sequences from -469 to +4081bp relative to the lqfR start codon.

(Lee et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval salivary gland

(Lee et al., 2009)

eye | somatic clone

(Lee and Fischer, 2012, Lee et al., 2009)

eye disc | somatic clone

(Lee et al., 2009)

imaginal disc

(Lee et al., 2009)

ommatidium | somatic clone

(Lee et al., 2009)

rhabdomere | somatic clone

(Lee et al., 2009)

Detailed Description

Statement

Reference

Homozygous eyes generated by the EGUF method are small and rough.

(Lee and Fischer, 2012)

Homozygotes die as third instar larvae at 25[o]C. The mutant larvae have small salivary glands that have small cells and have no imaginal discs.

Eyes composed of homozygous clones are malformed and smaller than normal.

Homozygous clones induced in the eye disc are always smaller than their wild-type twin spots, due to a decrease in the number of cells in the mutant clones. Ommatidia composed completely of homozygous cells are sometimes normally constructed, containing 8 photoreceptors arranged in a trapezoid, but these mutant ommatidia and all the photoreceptor cell rhabdomeres within them appear smaller than the wild-type cells surrounding them (the rhabdomeres are on average 45% the size of wild type). In mosaic ommatidia at the clone borders, the mutant cells are usually smaller than wild type, while the wild-type cells are of normal size.

(Lee et al., 2009)

lethal

(Lee et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

lqfR⁰³⁶⁸⁵/lqfR^Δ117 has partially lethal phenotype, enhanceable by arm³/arm[+]

(Lee and Fischer, 2012)

lqfR⁰³⁶⁸⁵/lqfR^Δ117 has partially lethal phenotype, enhanceable by arm⁸/arm[+]

(Lee and Fischer, 2012)

lqfR^Δ117 has decreased cell size | somatic clone phenotype, enhanceable by InR³³⁹

(Lee et al., 2009)

Enhancer of

Statement

Reference

lqfR^Δ117 is an enhancer of decreased cell size | somatic clone phenotype of InR³³⁹

(Lee et al., 2009)

Other

Statement

Reference

ds^38k/ds[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has some die during P-stage phenotype

(Lee and Fischer, 2012)

arm³/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has lethal - all die during P-stage phenotype

(Lee and Fischer, 2012)

arm⁸/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has lethal - all die during P-stage phenotype

(Lee and Fischer, 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

lqfR^Δ117 has rhabdomere | somatic clone phenotype, enhanceable by InR³³⁹

(Lee et al., 2009)

Enhancer of

Statement

Reference

lqfR^Δ117 is an enhancer of rhabdomere | somatic clone phenotype of InR³³⁹

(Lee et al., 2009)

Other

Statement

Reference

arm³/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has eye | P-stage phenotype

(Lee and Fischer, 2012)

arm³/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has leg | P-stage phenotype

(Lee and Fischer, 2012)

lqfR⁰³⁶⁸⁵/lqfR^Δ117, wg[+]/wg^l-17 has head | P-stage phenotype

(Lee and Fischer, 2012)

lqfR⁰³⁶⁸⁵/lqfR^Δ117, wg[+]/wg^l-17 has eye | P-stage phenotype

(Lee and Fischer, 2012)

arm³/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has wing | P-stage phenotype

(Lee and Fischer, 2012)

arm³/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has adult head capsule | P-stage phenotype

(Lee and Fischer, 2012)

arm⁸/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has eye | P-stage phenotype

(Lee and Fischer, 2012)

arm⁸/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has leg | P-stage phenotype

(Lee and Fischer, 2012)

arm⁸/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has wing | P-stage phenotype

(Lee and Fischer, 2012)

arm⁸/arm[+], lqfR⁰³⁶⁸⁵/lqfR^Δ117 has adult head capsule | P-stage phenotype

(Lee and Fischer, 2012)

Additional Comments

Genetic Interactions

Statement

Reference

arm³/+ ; lqfR⁰³⁶⁸⁵/lqfR^Δ117 and arm⁸/+ ; lqfR⁰³⁶⁸⁵/lqfR^Δ117 animals die in the pupal case. They have small or absent eyes, small head capsules and also have morphological defects in the head cuticle, wings and legs.

wg^l-17/+ ; lqfR⁰³⁶⁸⁵/lqfR^Δ117 adult escapers have severely defective eyes, ranging from kidney-shaped to nearly absent. They also have defects in the head cuticle.

(Lee and Fischer, 2012)

Photoreceptor cell rhabdomeres are on average 23% the size of wild type in InR³³⁹ lqfR^Δ117 double mutant clones in the eye (significantly smaller than in either single mutant).

(Lee et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

lqfR^SG62

(Lee et al., 2009)

Rescued by

lqfR^Δ117 is rescued by Scer\GAL4^Act5C.PI/lqfR^{a.UAS.Tag:MYC}

(Lee and Fischer, 2012)

lqfR^Δ117 is rescued by lqfR^{a.UAS.Tag:MYC}/Scer\GAL4^ey.PH