FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sra619
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General Information
Symbol
Dmel\sra619
Species
D. melanogaster
Name
FlyBase ID
FBal0194826
Feature type
allele
Associated gene
Dmel\sra
Associated Insertion(s)
P{lacW}sra619
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Horner, 2006)
Mutagen
P-element activity
(Horner, 2006)
Progenitor genotype
Associated Insertion(s)
P{lacW}sra619
Cytology
Description

The P{lacW} insertion is within the large intron of sra.

(Horner, 2006)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eggs laid by sraA426/sra619 mothers are usually arrested in anaphase I but a few eggs appear to be in meiosis II. The two spindles observed in such eggs are parallel to one another and they are usually asynchronous, with one in metaphase and the other in anaphase. In a few sraA426/sra619 eggs, some pycnotic chromosomes appear to separate from the main spindle and nucleate secondary spindles.

      sraA108/sra619 eggs are fertilized by sperm as the sperm nucleus can be observed inside the egg. However, the male pronucleus in fertilized eggs is much smaller than that of fully decondensed wild-type male pronuclei seen prior to pronuclear fusion.

      (Horner et al., 2006)

      Eggs laid by sraA108/sra619, sra687/sra619 and sraA426/sra619 mothers arrest during anaphase of the first meiotic division.

      The vitelline membranes of eggs laid by sra687/sra619, sraA108/sra619, sraA426/sra619 and sraUM3/sra619 mothers are cross-linked.

      (Horner, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      sraUM3

      (Horner, 2006)

      sraA426

      (Horner, 2006)

      sra687

      (Horner, 2006)

      sraA108

      (Horner, 2006)
      Rescued by

      sra619 is rescued by sracHa

      (Horner, 2006)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Revertants demonstrate the P{lacW} insertion causes the female sterile phenotype.

      (Horner, 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sra619
      (Horner, 2006)
      sra619
      (Horner et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)