FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Drp1+t9.4
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General Information
Symbol
Dmel\Drp1+t9.4
Species
D. melanogaster
Name
FlyBase ID
FBal0195692
Feature type
allele
Associated gene
Dmel\Drp1
Associated Insertion(s)
Carried in Construct
P{Drp1+t9.4}
Key Links
Transgenic product class
genomic_DNA
(Verstreken et al., 2005)
wild_type
(Verstreken et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Verstreken et al., 2005)
wild_type
(Verstreken et al., 2005)
Mutagen
in vitro construct
(Venken et al., 2006, Verstreken et al., 2005)
Progenitor genotype
Carried in construct
P{Drp1+t9.4}
Cytology
Description

9.35kb genomic fragment containing Drp1 sequences, obtained from BAC30P05.

(Verstreken et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
Drp1
Encoded product / tool
Drp1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1B9
      (Liu et al., 2011, Poole et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Drp1+t9.4 ameliorates the bioenergetic defects seen in the Pink1B9 Parkinson's model.

      (Liu et al., 2011)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      One copy of Drp1+t9.4 increases mitochondrial fission.

      (Rival et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      mAcon11, Drp1+t9.4, Acon[+] is a suppressor | partially of abnormal flight phenotype of Pink1B9

      (Esposito et al., 2013)

      mAcon1MB09176, Drp1+t9.4, Acon[+] is a suppressor | partially of abnormal flight phenotype of Pink1B9

      (Esposito et al., 2013)

      Drp1+t9.4 is a suppressor | partially of abnormal flight phenotype of Pink1B9

      (Esposito et al., 2013, Vilain et al., 2012, Poole et al., 2008)

      Drp1+t9.4 is a suppressor | partially of visible phenotype of Pink1B9

      (Poole et al., 2008)

      Drp1+t9.4 is a suppressor | partially of abnormal locomotor behavior phenotype of Pink1B9

      (Poole et al., 2008)
      NOT Suppressor of
      Statement
      Reference

      Drp1+t9.4 is a non-suppressor of male sterile phenotype of Pink1B9

      (Vilain et al., 2012)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Drp1+t9.4 is a suppressor of mitochondrion phenotype of Pink1unspecified

      (Rival et al., 2011)

      Drp1+t9.4 is a suppressor | partially of adult thorax phenotype of Pink1B9

      (Poole et al., 2008)

      Drp1+t9.4 is a suppressor | partially of mitochondrion phenotype of Pink1B9

      (Poole et al., 2008)
      NOT Suppressor of
      Statement
      Reference

      Drp1+t9.4 is a non-suppressor of mitochondrion phenotype of Scer\GAL4ple.PF, mAcon1UAS.cEa

      (Esposito et al., 2013)

      Drp1+t9.4 is a non-suppressor of mitochondrion phenotype of Scer\GAL4ple.PF, mAcon1S677A.UAS

      (Esposito et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Drp1+t9.4 does not rescue the defects in mitochondrial morphology seen in dopaminergic neurons expressing either AconS677A.Scer\UAS or AconScer\UAS.cEa under the control of Scer\GAL4ple.PF.

      Pink1B9 ; Acon1/+ ; Drp1+t9.4/+ animals show increased flight ability compared to either Pink1B9 ; Acon1/+ or Pink1B9 ; Drp1+t9.4/+ animals.

      Pink1B9 ; AconMB09176/+ ; Drp1+t9.4/+ animals show increased flight ability compared to either Pink1B9 ; AconMB09176/+ or Pink1B9 ; Drp1+t9.4/+ animals.

      (Esposito et al., 2013)

      Drp1+t9.4 opa1-likeunspecified/+ Df(3L)Pmi-PGRP-LD flies show no rescue of the Df(3L)Pmi-PGRP-LD abnormal mitochondrial morphology phenotype.

      (Rival et al., 2011)

      Expression of Drp1+t9.4 results in partial rescue of the thoracic indentation, impaired flight, impaired climbing, and mitochondrial morphological phenotypes of Pink1B9 hemizygous mutants.

      (Poole et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Drp1+t9.4
      drp1TGnt
      (Poole et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)