Open Close
General Information
Symbol
Dmel\Atx2GD11562
Species
D. melanogaster
Name
FlyBase ID
FBal0198800
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Atx2RNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Atx2GD11562 under the control of Scer\GAL4NP1227 (limited to the adult stages using Scer\GAL80ts.αTub84B) has no effect on the short term habituation (STH) seen following exposure to either ethyl butyrate (EB) or CO[[2]], but results in a complete block of long term habituation (LTH) to this odorant.

Expression of Atx2GD11562 under the control of Scer\GAL4P2.4.Pdf (co-expressed with Dcr-2Scer\UAS.cDa) increases the period of circadian locomotor darkness.

Expression of Atx2GD11562 under the control of Scer\GAL4GH146 completely blocks the long-term habituation (LTH) seen when flies are exposed to ethyl butyrate (EB) for 4 days. LTH to CO[[2]] is unaffected. Short term habituation (STH) in response to 1 hour of EB exposure is also unaffected, as is the EB-avoidance response. In contrast to controls, no increase is seen in the volume of either the DM5 glomerulus or the DM2 glomerulus in response to 4h EB exposure. The volume of the V glomerulus increases as in controls. There is a significant reduction in EB-evoked calcium flux compared to controls. A block in EB-specific LTH is also seen when expression of Atx2GD11562 is restricted to the adult stages using Scer\GAL80ts.αTub84B.

Expression of Atx2GD11562 in the CO[[2]]-responsive VPN under the control of Scer\GAL4VPN selectively blocks LTH to CO[[2]] without altering either STH to CO[[2]] or the naive olfactory response to CO[[2]]. No growth is seen in the volume of the V glomerulus, but normal EB-induced growth of the DM5 glomerulus is seen.

Expression under the control of Scer\GAL41407 results in an increase in the average size of neuroblasts in the larval brain compared to controls.

Adults expressing Atx2GD11562 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4Mef2.PR results in late pupal lethality.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Phenotype Manifest In
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Atx2GD11562 does not suppress the cell death phenotype seen in the eyes of flies expressing thdsRNA.Scer\UAS under the control of Scer\GAL4GMR.PU.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 2 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Atx2GD11562
Name Synonyms
Secondary FlyBase IDs
    References (12)