FlyBase Allele Report: Dmel\Pp4-19C[GD9561]

General Information

Symbol

Dmel\Pp4-19C^GD9561

Species

D. melanogaster

Name

FlyBase ID

FBal0208110

Feature type

allele

Associated gene

Dmel\Pp4-19C

Associated Insertion(s)

Carried in Construct

P{GD9561}

Also Known As

PP4-19C^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD9561}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD9561

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of chromosome 16p11.2 deletion syndrome, 593-kb

CEA

(Yusuff et al., 2020, Iyer et al., 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of chromosome 16p11.2 deletion syndrome, 593-kb

is ameliorated by Atx2^GD11562

(Iyer et al., 2018)

is ameliorated by Pten^KK109278

(Iyer et al., 2018)

is ameliorated by arm^KK102545

(Iyer et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

mesonotum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

neuromuscular junction, with Scer\GAL4^elav-C155

(Bulat et al., 2014)

synapse, with Scer\GAL4^elav-C155

(Bulat et al., 2014)

Detailed Description

Statement

Reference

Presynaptic expression of Pp4-19C^GD9561 under the control of Scer\GAL4^elav-C155 causes synaptic retractions in less than 10% of synapses.

(Bulat et al., 2014)

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in loss of neuroblasts in the larval brain without any change in size of the remaining neuroblasts.

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in either shorter neuroblast lineages (less daughter cells per neuroblast) or longer neuroblast lineages (more daughter cells per neuroblast) in the larval brain compared to controls, depending on the insertion line used.

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in mild defects in the shape of ganglion mother cells in the larval brain.

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in mild defects in the shape of neuroblasts in the larval brain.

(Neumüller et al., 2011)

Expression under the control of Scer\GAL4^Mef2.PR results in late pupal lethality.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 50-60% of the Scer\GAL4^pnr-MD237-expressing area of the notum.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

9561

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v25317

w¹¹¹⁸; P{GD9561}v25317

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 2 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

9561

Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells

9561

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

PP4-19C^RNAi

(Zhang et al., 2016, Chai et al., 2013)

PPP4C^pp4-19C

(Iyer et al., 2018)

Pp4-19C^GD9561

(Yusuff et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (20)

Report Sections

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