FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Usp5GD6741
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General Information
Symbol
Dmel\Usp5GD6741
Species
D. melanogaster
Name
FlyBase ID
FBal0199681
Feature type
allele
Associated gene
Dmel\Usp5
Associated Insertion(s)
Carried in Construct
P{GD6741}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD6741}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD6741
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Usp5GD6741 under the control of Scer\GAL4how-24B (but not Scer\GAL4Toll-6-D42) results in neuromuscular junction morphological defects and decreased bouton number in third instar larvae.

      (Wang et al., 2017)

      Expression of Usp5GD6741 in the eye under the control of Scer\GAL4ey.PU results in rough and small (occasionally missing) eyes.

      Expression of Usp5GD6741 in the wing under the control of Scer\GAL4nub.PU results in uninflated vestigial or missing wings.

      (Kovacs et al., 2015)

      Expression of Usp5GD6741 under the control of Scer\GAL4ey.PU results in a small eye phenotype.

      Expression of Usp5GD6741 in the dorsal part of the eye disc under the control of Scer\GAL4mirr-DE results in extremely high levels of apoptosis in the dorsal region of third instar larvae, anterior to the morphogenetic furrow.

      (Fan et al., 2014)

      Many Scer\GAL4elav.PU, CG12082GD6741 animals die as pharates; those that survive are slower than controls and are dead by 40 days. Expression of CG12082GD6741 using a weaker Scer\GAL4elav.PU results in mildly slower adults.

      Scer\GAL4repo, CG12082GD6741 animals die as pharates and young adults.

      (Tsou et al., 2012)

      Expression of CG12082GD6741 under the control of Scer\GAL4bbg-C96 results in wrinkled wings and loss of wing margin bristles.

      (Zhang et al., 2012)

      Adults expressing Usp5GD6741 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) show significantly reduced avoidance of noxious temperature (46[o]C) compared to control flies.

      Adults expressing Usp5GD6741 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) show no significant change in the kinetics of high temperature (46[o]C) induced paralysis compared to control flies.

      (Neely et al., 2010)

      Expression under the control of Scer\GAL4Mef2.PR results in early pupal lethality.

      (Schnorrer et al., 2010)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      Usp5GD6741, Scer\GAL4GMR.PFa is a non-enhancer of eye phenotype of DroncUAS.cSa, Scer\GAL4GMR.PFa

      (Sinenko, 2017)

      Usp5GD6741, Scer\GAL4GMR.PFa is a non-enhancer of eye phenotype of DroncS130A.UAS.cSa, Scer\GAL4GMR.PFa

      (Sinenko, 2017)
      NOT Suppressor of
      Statement
      Reference

      Usp5GD6741, Scer\GAL4GMR.PFa is a non-suppressor of eye phenotype of DroncUAS.cSa, Scer\GAL4GMR.PFa

      (Sinenko, 2017)

      Usp5GD6741, Scer\GAL4GMR.PFa is a non-suppressor of eye phenotype of DroncS130A.UAS.cSa, Scer\GAL4GMR.PFa

      (Sinenko, 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The photoreceptor depigmentation phenotype characteristic for adult flies expressing either DroncUAS.cSa or DroncS130A.UAS.cSa under the control of Scer\GAL4GMR.PFa is not significantly modified by the co-expression of Usp5[GD6741].

      (Sinenko, 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG12082GD6741
      Usp5GD6741
      Name Synonyms
      Secondary FlyBase IDs
        References (15)