FlyBase Allele Report: Dmel\Sln[GD1940]

General Information

Symbol

Dmel\Sln^GD1940

Species

D. melanogaster

Name

FlyBase ID

FBal0205809

Feature type

allele

Associated gene

Dmel\Sln

Associated Insertion(s)

Carried in Construct

P{GD1940}

Also Known As

Sln RNAi, UAS-Sln RNAi GD1940

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1940}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1940

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased efficacy of memory | adult stage | calorie restriction conditional, with Scer\GAL4^VT030559

(Silva et al., 2022)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing Sln^GD1940 for 2 days under the combined control of Scer\GAL4^VT030559 and Gal80[ts] (for temporal control of expression) exhibit decreased associative olfactory memory under starvation conditions, but not when fed.

(Silva et al., 2022)

The accumulation of lipid droplets in glial cells in the vicinity of adult photoreceptor neurons expressing ND-42^ninaE.GD6220 is not suppressed by Scer\GAL4^54C-driven (glial) expression of Sln^GD1940 while expression under the control of the neuronal Scer\GAL4^elav.PLu driver efficiently rescues the phenotype.

Expression of Sln^GD1940 in the ey>flip whole-eye clones mutant for either sicily^E or Marf^B ameliorates the lipid droplet accumulation in retinal glial cells in adult flies and also improves the photoreceptor degeneration phenotype.

The accumulation of lipid droplets in the retinal glia of adult flies expressing either SREBP^UAS.cKa or bsk^Scer\UAS.cBa under the control of Scer\GAL4^nSyb.PS is significantly suppressed by co-expression of Sln^GD1940.

(Liu et al., 2017)

Adults expressing Sln^GD1940 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in viable flies or late pupal lethality.

(Schnorrer et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development