FlyBase Allele Report: Dmel\DUBAI[GD14040]

General Information

Symbol

Dmel\DUBAI^GD14040

Species

D. melanogaster

Name

FlyBase ID

FBal0206008

Feature type

allele

Associated gene

Dmel\DUBAI

Associated Insertion(s)

Carried in Construct

P{GD14040}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD14040}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD14040

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

(Tsou et al., 2012)

abnormal locomotor behavior | adult stage, with Scer\GAL4^sqh.PW

(Tsou et al., 2012)

partially lethal - majority die, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

some die during pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with DUBAI^KG07439, Scer\GAL4^GMR.PFa

(Yang et al., 2014)

visible, with Scer\GAL4^GMR.PFa

(Yang et al., 2014)

Phenotype Manifest In

eye, with DUBAI^KG07439, Scer\GAL4^GMR.PFa

(Yang et al., 2014)

eye, with Scer\GAL4^GMR.PFa

(Yang et al., 2014)

Detailed Description

Statement

Reference

Expression of one copy of DUBAI^GD14040 under the control of Scer\GAL4^GMR.PFa results in a rough eye phenotype at 29[o]C. The phenotype is more severe if the flies are either also heterozygous for DUBAI^KG07439 or are carrying two copies of DUBAI^GD14040.

(Yang et al., 2014)

Scer\GAL4^sqh.PW, CG8830^GD14040 adults are slower than controls.

Scer\GAL4^elav.PU, CG8830^GD14040 adults are slower than controls.

(Tsou et al., 2012)

Expression of CG8830^GD14040 under the control of Scer\GAL4^bbg-C96 does not result in a wing phenotype.

Expression of CG8830^GD14040 under the control of Scer\GAL4^dpp.PU does not result in a bristle phenotype.

(Zhang et al., 2012)

Adults expressing DUBAI^GD14040 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14040

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

DUBAI^GD14040 has visible phenotype, suppressible by Diap1^UAS.cHa/Scer\GAL4^GMR.PFa

(Yang et al., 2014)

DUBAI^GD14040 has visible phenotype, suppressible by BacA\p35^UAS.cHa/Scer\GAL4^GMR.PFa

(Yang et al., 2014)

Enhancer of

Statement

Reference

DUBAI^GD14040, Scer\GAL4^GMR.PFa is an enhancer of visible phenotype of Scer\GAL4^GMR.PFa, rpr^UAS.C

(Yang et al., 2014)

DUBAI^GD14040/Scer\GAL4^GMR.PFa is an enhancer of visible phenotype of hid^GMR.PG

(Yang et al., 2014)

NOT Enhancer of

Statement

Reference

DUBAI^GD14040, Scer\GAL4^GMR.PFa is a non-enhancer of visible | adult stage phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

DUBAI^GD14040, Scer\GAL4^GMR.PFa is a non-enhancer of abnormal eye color phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

DUBAI^GD14040, Scer\GAL4^GMR.PFa is a non-enhancer of visible | adult stage phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

DUBAI^GD14040, Scer\GAL4^GMR.PFa is a non-enhancer of abnormal eye color phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

NOT Suppressor of

Statement

Reference

DUBAI^GD14040, Scer\GAL4^GMR.PFa is a non-suppressor of visible | adult stage phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

DUBAI^GD14040, Scer\GAL4^GMR.PFa is a non-suppressor of abnormal eye color phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

DUBAI^GD14040, Scer\GAL4^GMR.PFa is a non-suppressor of visible | adult stage phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

DUBAI^GD14040, Scer\GAL4^GMR.PFa is a non-suppressor of abnormal eye color phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Other

Statement

Reference

DUBAI^GD14040, Scer\GAL4^GMR.PFa, grim^GMR.PC has visible phenotype

(Yang et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

DUBAI^GD14040 has eye phenotype, suppressible by Diap1^UAS.cHa/Scer\GAL4^GMR.PFa

(Yang et al., 2014)

DUBAI^GD14040 has eye phenotype, suppressible by BacA\p35^UAS.cHa/Scer\GAL4^GMR.PFa

(Yang et al., 2014)

Enhancer of

Statement

Reference

DUBAI^GD14040, Scer\GAL4^GMR.PFa is an enhancer of eye phenotype of Scer\GAL4^GMR.PFa, rpr^UAS.C

(Yang et al., 2014)

DUBAI^GD14040/Scer\GAL4^GMR.PFa is an enhancer of eye phenotype of hid^GMR.PG

(Yang et al., 2014)

NOT Enhancer of

Statement

Reference

DUBAI^GD14040, Scer\GAL4^GMR.PFa is a non-enhancer of eye phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

DUBAI^GD14040, Scer\GAL4^GMR.PFa is a non-enhancer of eye phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

NOT Suppressor of

Statement

Reference

DUBAI^GD14040, Scer\GAL4^GMR.PFa is a non-suppressor of eye phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

DUBAI^GD14040, Scer\GAL4^GMR.PFa is a non-suppressor of eye phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Other

Statement

Reference

DUBAI^GD14040, Scer\GAL4^GMR.PFa, grim^GMR.PC has eye phenotype

(Yang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The photoreceptor depigmentation phenotype characteristic for adult flies expressing either Dronc^UAS.cSa or Dronc^{S130A.UAS.cSa} under the control of Scer\GAL4^GMR.PFa is not significantly modified by the co-expression of DUBAI^GD14040.

(Sinenko, 2017)

Co-expression of grim^GMR.PC and DUBAI^GD14040 (expressed under the control of Scer\GAL4^GMR.PFa) results in a significant loss of pigment cells in the eye.

Co-expression of th^Scer\UAS.cHa suppresses the eye defects caused by expression of DUBAI^GD14040 under the control of Scer\GAL4^GMR.PFa.

(Yang et al., 2014)

Xenogenetic Interactions

Statement

Reference

Co-expression of BacA\p35^Scer\UAS.cHa suppresses the eye defects caused by expression of DUBAI^GD14040 under the control of Scer\GAL4^GMR.PFa.

(Yang et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v28960

w¹¹¹⁸; P{GD14040}v28960

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14040

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG8830^GD14040

DUBAI^GD14040

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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